CsrB/RsmB RNA family explained

CsrB/RsmB RNA family
Symbol:CsrB
Rfam:RF00018
Rna Type:Gene
sRNA
Tax Domain:Bacteria

The CsrB RNA is a non-coding RNA that binds to approximately 9 to 10 dimers of the CsrA protein.[1] The CsrB RNAs contain a conserved motif CAGGXXG that is found in up to 18 copies and has been suggested to bind CsrA. The Csr regulatory system has a strong negative regulatory effect on glycogen biosynthesis, glyconeogenesis and glycogen catabolism and a positive regulatory effect on glycolysis.[2] In other bacteria such as Erwinia carotovora the RsmA protein has been shown to regulate the production of virulence determinants, such extracellular enzymes.[3] RsmA binds to RsmB regulatory RNA which is also a member of this family.

RsmB RNA was shown to be upregulated by GacS/A system, and increase downstream T3SS gene expression.[4] FlhDC, the master regulator of flagellar genes, also activates rsmB RNA production.[5] A regulatory network have been revealed connecting rsmB, FlhDC and T3SS.[6]

It has been shown to play role in the biocontrol activity of Rahnella aquatilis HX2 (a biocontrol agent producing antibacterial substance).[7]

See also

External links

Notes and References

  1. Babitzke P, Romeo T . CsrB sRNA family: sequestration of RNA-binding regulatory proteins . Current Opinion in Microbiology . 10 . 2 . 156–163 . April 2007 . 17383221 . 10.1016/j.mib.2007.03.007 .
  2. Liu MY, Gui G, Wei B, Preston JF, Oakford L, Yüksel U, Giedroc DP, Romeo T . The RNA molecule CsrB binds to the global regulatory protein CsrA and antagonizes its activity in Escherichia coli . The Journal of Biological Chemistry . 272 . 28 . 17502–17510 . July 1997 . 9211896 . 10.1074/jbc.272.28.17502 . free .
  3. Cui Y, Chatterjee A, Liu Y, Dumenyo CK, Chatterjee AK . Identification of a global repressor gene, rsmA, of Erwinia carotovora subsp. carotovora that controls extracellular enzymes, N-(3-oxohexanoyl)-L-homoserine lactone, and pathogenicity in soft-rotting Erwinia spp . Journal of Bacteriology . 177 . 17 . 5108–5115 . September 1995 . 10.1128/jb.177.17.5108-5115.1995 . 7665490 . 177290 .
  4. Yang S, Peng Q, Zhang Q, Yi X, Choi CJ, Reedy RM, Charkowski AO, Yang CH . Dynamic regulation of GacA in type III secretion, pectinase gene expression, pellicle formation, and pathogenicity of Dickeya dadantii (Erwinia chrysanthemi 3937) . Molecular Plant-Microbe Interactions . 21 . 1 . 133–142 . January 2008 . 18052890 . 10.1094/MPMI-21-1-0133 . free .
  5. Cui Y, Chatterjee A, Yang H, Chatterjee AK . Regulatory network controlling extracellular proteins in Erwinia carotovora subsp. carotovora: FlhDC, the master regulator of flagellar genes, activates rsmB regulatory RNA production by affecting gacA and hexA (lrhA) expression . Journal of Bacteriology . 190 . 13 . 4610–4623 . July 2008 . 18441056 . 2446818 . 10.1128/JB.01828-07 .
  6. Yuan X, Khokhani D, Wu X, Yang F, Biener G, Koestler BJ, Raicu V, He C, Waters CM, Sundin GW, Tian F, Yang CH . Cross-talk between a regulatory small RNA, cyclic-di-GMP signalling and flagellar regulator FlhDC for virulence and bacterial behaviours . Environmental Microbiology . 17 . 11 . 4745–4763 . November 2015 . 26462993 . 10.1111/1462-2920.13029 . 6652182 .
  7. Mei L, Xu S, Lu P, Lin H, Guo Y, Wang Y . CsrB, a noncoding regulatory RNA, is required for BarA-dependent expression of biocontrol traits in Rahnella aquatilis HX2 . PLOS ONE . 12 . 11 . e0187492 . 2017 . 29091941 . 5665550 . 10.1371/journal.pone.0187492 . 2017PLoSO..1287492M . free .

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