Cryptotope Explained

A cryptotope is an antigenic site or epitope hidden in a protein or virion by surface subunits. Cryptotopes are antigenically active only after the dissociation of protein aggregates and virions.[1] Some infectious pathogens are known to escape immunological targeting by B-cells by masking antigen-binding sites as cryptotopes.[2] A cryptotope can also be referred to as a cryptic epitope.Cryptotopes are becoming important for HIV vaccine research as a number of studies have shown that cryptic epitopes can be revealed or exposed when HIV gp120 binds to CD4.[3]

References

  1. Web site: Antigenicity and Immunogenicity of Viral Proteins. Regenmortel. Marc. Elsevier. 2008.
  2. Reider. Franz. Biebl. Julia. etal. Microbial Cryptotopes are Prominent Targets of B-cell Immunity. Scientific Reports. 6. 31657. 22 July 2016. 10.1038/srep31657. 27539094. 4990913.
  3. Characterization of Conserved Human Immunodeficiency Virus Type 1 gpl20 Neutralization Epitopes Exposed upon gpl20-CD4 Binding. Thali. Marcus. American Society for Microbiology. Journal of Virology. 67. 7. July 1993. 3978–3988. 10.1128/jvi.67.7.3978-3988.1993 . 7685405 . 237765 .

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