Cryptolepine Explained

Cryptolepine is an alkaloid with antimalarial and cytotoxic properties, in vitro and in mice. It is able to intercalate into DNA at the cytosine-cytosine sites.[1] [2] Because of its toxicity, Cryptolepine is not considered appropriate for use as an anti-malarial drug in humans.[3]

Cryptolepine can be found in the roots of the West African plant, Cryptolepis sanguinolenta.[1]

Notes and References

  1. Wright . C. W.. Addae-Kyereme . J.. Breen . A. G.. Brown . J. E.. Cox . M. F.. Croft . S. L.. Gökçek . Y.. Kendrick . H.. Phillips . R. M.. Pollet . P. L.. Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents. Journal of Medicinal Chemistry. 44. 19. 3187–3194. 2001. 11543688 . 10.1021/jm010929+.
  2. Onyeibor . O.. Croft . S. L.. Dodson . H. I.. Feiz-Haddad . M.. Kendrick . H.. Millington . N. J.. Parapini . S.. Phillips . R. M.. Seville . S.. Shnyder . S. D.. Taramelli . D.. Wright . C. W.. 10.1021/jm040893w. Synthesis of Some Cryptolepine Analogues, Assessment of Their Antimalarial and Cytotoxic Activities, and Consideration of Their Antimalarial Mode of Action. Journal of Medicinal Chemistry. 48. 7. 2701–2709. 2005. 15801861. 2434/17291. free.
  3. Gopalan . Rajendran C. . Emerce . Esra . Wright . Colin W. . Karahalil . Bensu . Karakaya . Ali E. . Anderson . Diana . Effects of the anti-malarial compound cryptolepine and its analogues in human lymphocytes and sperm in the Comet assay . Toxicology Letters . December 2011 . 207 . 3 . 322–325 . 10.1016/j.toxlet.2011.09.010. 21946165 .

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