| Cruz del Eje | |
| Native Name Lang: | es |
| Settlement Type: | City |
| Pushpin Map: | Argentina |
| Pushpin Map Caption: | Location of Cruz del Eje in Argentina |
| Coordinates: | -30.7333°N -112°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Type2: | Department |
| Subdivision Name2: | Cruz del Eje |
| Leader Title: | Mayor |
| Leader Name: | Claudio Sebastián Farías |
| Unit Pref: | Metric |
| Elevation M: | 449 |
| Population Total: | 30,680 |
| Population As Of: | 2010 census |
| Population Density Km2: | auto |
| Timezone1: | ART |
| Utc Offset1: | -3 |
| Postal Code Type: | CPA base |
| Postal Code: | X5280 |
| Area Code Type: | Dialing code |
| Area Code: | +54 3549 |
| Website: | Official website |
Cruz del Eje is a city in the province of Córdoba, Argentina. It had about 30,000 inhabitants at the . It is the head town of the department of the same name, which has a population of about 52,000.
The area of the city was originally inhabited by Comechingón aboriginals, which were thoroughly displaced or exterminated by the Spanish conquistadores by the end of the 17th century. The first official owner of the lands was Francisco de Baigorri, as recorded on September 22, 1735, which is taken as the foundation date of the city.
The settlement was linked by a road to the provincial capital, Córdoba, in 1878, and it was declared a municipality on May 8, 1890; at the time it had about 4,000 inhabitants. On the latter year the train station was also opened. Cruz del Eje's position as a railroad node would lead to a rapid growth in importance; the railway workshops were dismantled in the 1970s. The Cruz del Eje Reservoir, initiated by Governor Amadeo Sabattini, was completed in 1943. The city grew subsequently as a tourist destination.
President Arturo Illia maintained a medical practice in Cruz del Eje from 1928 until his election as President of Argentina in 1963. President Illia's Cruz del Eje home was made a museum in 2003.