Cruentaren Explained

Cruentarens are a group of macrolides secreted by the myxobacteria Byssovorax cruenta.[1] There are two isomers (cruentaren A and B) have been isolated.[2] They each have a molecular formula of C33H51NO8 and molecular weight 589 g/mol. Cruentaren A strongly inhibits the growth of yeasts and filamentous fungi, and inhibits the proliferation of different cancer cell lines in vitro,[3] including a multidrug-resistant KB line. Cruentaren B shows only marginal cytotoxicity and no antifungal activity.

Notes and References

  1. Journal of Antibiotics . 0021-8820 . 2006 . 59 . 10 . Cruentaren, a new antifungal salicylate-type macrolide from Byssovorax cruenta (Myxobacteria) with inhibitory effect on mitochondrial ATPase activity : Fermentation and biological properties . 664–668 . Kunze . Brigitte . Heinrich Steinmetz . Gerhard Höfle . Markus Huss . Helmut Wieczorek . Hans Reichenbach . 10.1038/ja.2006.89 . 17191683. free .
  2. 10.1002/ejoc.200600421 . Isolation and Structure Elucidation of Cruentarens A and B — Novel Members of the Benzolactone Class of ATPase Inhibitors from the Myxobacterium Byssovorax cruenta . European Journal of Organic Chemistry . 2006 . 22 . 5036–5044 . Jundt . Larissa . Steinmetz . Heinrich . Luger . Peter . Weber . Manuela . Kunze . Brigitte . Reichenbach . Hans . Höfle . Gerhard . 2006 .
  3. 10.1016/j.febslet.2007.06.069. 17624334. Cruentaren A, a highly cytotoxic benzolactone from Myxobacteriais a novel selective inhibitor of mitochondrial F1-ATPases. FEBS Letters. 581. 18. 3523–3527. 2007. Kunze. Brigitte. Sasse. Florenz. Wieczorek. Helmut. Huss. Markus. free.

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