Crohns MAP Vaccine explained

The Crohns MAP Vaccine is an experimental Viral vector vaccine intended to prevent or treat Crohn's disease, by provoking an immune response to one possible causative agent of the disease, Mycobacterium avium subsp. paratuberculosis.[1] [2] [3] [4] The vaccine is currently about to begin Phase 2 of its development.[5] [6] One of the scientists involved with this research is Thomas Borody, known for his work in developing the 'Triple Therapy' for treating ulcers caused by Helicobacter pylori.[7]

Notes and References

  1. Agrawal. Gaurav. Clancy. Annabel. Huynh. Roy. Borody. Thomas. 2020-04-09. Profound remission in Crohn's disease requiring no further treatment for 3–23 years: a case series. Gut Pathogens. 12. 1. 16. 10.1186/s13099-020-00355-8. 1757-4749. 7144342. 32308741 . free .
  2. Qasem. Ahmad. Elkamel. Erij. Naser. Saleh A.. November 2020. Anti-MAP Triple Therapy Supports Immunomodulatory Therapeutic Response in Crohn's Disease through Downregulation of NF-κB Activation in the Absence of MAP Detection. Biomedicines. en. 8. 11. 513. 10.3390/biomedicines8110513. 33217961. 7698721. free.
  3. 2019-02-01. Chronic regional intestinal inflammatory disease: A trans-species slow infection?. Comparative Immunology, Microbiology and Infectious Diseases. en. 62. 88–100. 10.1016/j.cimid.2018.12.001. 0147-9571. Balseiro. Ana. Perez. Valentin. Juste. Ramon A.. 30711052. 73449846 .
  4. Feller. Martin. Huwiler. Karin. Stephan. Roger. Altpeter. Ekkehardt. Shang. Aijing. Furrer. Hansjakob. Pfyffer. Gaby E. Jemmi. Thomas. Baumgartner. Andreas. Egger. Matthias. September 2007. Mycobacterium avium subspecies paratuberculosis and Crohn's disease: a systematic review and meta-analysis. The Lancet Infectious Diseases. 7. 9. 607–613. 10.1016/s1473-3099(07)70211-6. 17714674. 1473-3099.
  5. Web site: Crohn's MAP Vaccine. 2021-06-19. Crohn's MAP Vaccine. en-GB.
  6. Web site: The Crohn's Vaccine. 2021-06-19. Crohn's MAP Vaccine. en-GB.
  7. Web site: Putting MAP on the Map. 2021-06-19. Crohn's MAP Vaccine. en-GB.

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