Crisugabalin Explained
| Legal Status: | Investigational |
| Cas Number: | 2209104-84-5 |
| C: | 12 |
| H: | 19 |
| N: | 1 |
| O: | 2 |
Crisugabalin (HSK16149) is a selective GABA analog in development for the treatment of chronic pain. It has a wider therapeutic index than pregabalin, which as a similar mechanism of action. It is in Phase III trials as of 2023.[1] [2] The drug can be administered with or without food.[3]
See also
Notes and References
- Gou . Xiaoli . Yu . Xiaojuan . Bai . Dongdong . Tan . Bowei . Cao . Pingfeng . Qian . Meilin . Zheng . Xiaoxiao . Chen . Lei . Shi . Zongjun . Li . Yao . Ye . Fei . Liang . Yong . Ni . Jia . Pharmacology and Mechanism of Action of HSK16149, a Selective Ligand of α2δ Subunit of Voltage-Gated Calcium Channel with Analgesic Activity in Animal Models of Chronic Pain . The Journal of Pharmacology and Experimental Therapeutics . March 2021 . 376 . 3 . 330–337 . 10.1124/jpet.120.000315 . 1521-0103. free . 33293377 .
- Guo . Xiaohui . Zhang . Tingting . Yuan . Geheng . Yukun . Li . Hua Ma . Jian . Hong-Mei . Li . [10.2337/db23-224-OR 224-OR: The Efficacy and Safety of HSK 16149 in Chinese with Diabetic Peripheral Neuropathic Pain—A Randomized, Double-Blinded, Placebo and Pregabalin-Controlled Phase II/III Study ]. Diabetes . 2023 . 72 . Supplement_1 . 10.2337/db23-224-OR . 259442836 . en . 0012-1797.
- Wu . Qingqing . Zhu . Huijuan . Song . Rong . Zhang . Mengqi . Li . Fangqiong . Zeng . Weifang . Wang . Wei . Jia . Jingying . Yu . Chen . Liu . Yanmei . Effect of a high-fat and high-calorie food on the pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy subjects . Pharmacology Research & Perspectives . June 2023 . 11 . 3 . e01102 . 10.1002/prp2.1102. free . 37208866 . 10199234 .
