| Cristalino River | |
| Pushpin Map: | Brazil |
| River System: | Teles Pires |
| Source1 Location: | Nascentes da Serra do Cachimbo Biological Reserve, Pará |
| Mouth Location: | Teles Pires |
| Mouth Coordinates: | -9.6353°N -55.9289°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Brazil |
The Cristalino River (Portuguese: Rio Cristalino) is a river of the states of Pará and Mato Grosso in western Brazil. It is a tributary of the Teles Pires.
The river rises in the Nascentes da Serra do Cachimbo Biological Reserve, a strictly protected conservation unit established in 2005 in the state of Pará.It is an indirect tributary of the Tapajós.
After crossing the border into Mato Grosso the river flows through the Cristalino State Park, established in 2001, before entering the Teles Pires.The river is navigable throughout the state park, despite the large number of submerged rocks and small rapids along its course.