Crinecerfont Explained

Legal Status:	Investigational
Synonyms:	SSR-125543
Cas Number:	752253-39-7
Pubchem:	5282340
Unii:	MFT24BX55I
Iupac Name:	4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1''S'')-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thiazol-2-amine
C:	27
H:	28
Cl:	1
F:	1
N:	2
O:	1
S:	1

Crinecerfont is a corticotropin-releasing factor type 1 receptor (CRF1R) antagonist developed to treat classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21OHD). It is hoped to reduce the need for long-term, high dose glucocorticoid therapy and its associated adverse effects in people with CAH.^{[1] [2] [3] [4]}

Notes and References

1. Auchus . Richard J . Sarafoglou . Kyriakie . Fechner . Patricia Y . Vogiatzi . Maria G . Imel . Erik A . Davis . Shanlee M . Giri . Nagdeep . Sturgeon . Julia . Roberts . Eiry . Chan . Jean L . Farber . Robert H . Crinecerfont Lowers Elevated Hormone Markers in Adults With 21-Hydroxylase Deficiency Congenital Adrenal Hyperplasia . The Journal of Clinical Endocrinology & Metabolism . 17 February 2022 . 107 . 3 . 801–812 . 10.1210/clinem/dgab749. 34653252 . 8851935 .
2. Newfield . Ron S . Sarafoglou . Kyriakie . Fechner . Patricia Y . Nokoff . Natalie J . Auchus . Richard J . Vogiatzi . Maria G . Jeha . George S . Giri . Nagdeep . Roberts . Eiry . Sturgeon . Julia . Chan . Jean L . Farber . Robert H . Crinecerfont, a CRF1 Receptor Antagonist, Lowers Adrenal Androgens in Adolescents With Congenital Adrenal Hyperplasia . The Journal of Clinical Endocrinology & Metabolism . 18 October 2023 . 108 . 11 . 2871–2878 . 10.1210/clinem/dgad270. 37216921 . 10583973 .
3. Auchus . Richard J . Sarafoglou . Kyriakie . Fechner . Patricia Y . Vogiatzi . Maria . Giri . Nagdeep . Roberts . Eiry . Sturgeon . Julia . Farber . Robert . OR25-03 The Effects of Crinecerfont (NBI-74788), a Novel CRF1 Receptor Antagonist, on Adrenal Androgens and Precursors in Patients with Classic Congenital Adrenal Hyperplasia: Results from A Multiple-Dose Phase 2 Study . Journal of the Endocrine Society . 8 May 2020 . 4 . Supplement_1 . 10.1210/jendso/bvaa046.221 . free . 7209526 .
4. Auchus . Richard . Chan . Jean . Farber . Robert . Fechner . Patricia . Giri . Nagdeep . Nokoff . Natalie . Roberts . Eiry . Sarafoglou . Kyriakie . Sturgeon . Julia . Vogiatzi . Maria . Newfield . Ron . OR18-4 Crinecerfont (NBI-74788), a Novel CRF1 Receptor Antagonist, Lowers Adrenal Androgens and Precursors in Adolescents with Classic Congenital Adrenal Hyperplasia . Journal of the Endocrine Society . 1 November 2022 . 6 . Supplement_1 . A618 . 10.1210/jendso/bvac150.1281 . free . 9625506 .