Crc (protein) explained

Symbol:Crc
Crc
Pfam:PF03372
Cdd:cd08372

The Catabolite repression control (Crc) protein participates in suppressing expression of several genes involved in utilization of carbon sources in Pseudomonas bacteria.[1] Presence of organic acids triggers activation of Crc and in conjunction with the Hfq protein genes that metabolize a given carbon source are downregulated until another more favorable carbon source is depleted.[2] Crc-mediated regulation impact processes such as biofilm formation,[3] virulence[4] and antibiotic susceptibility.[5]

Interactions

Hfq and Crc bind to A-rich sequences in the ribosome binding sites of genes that code for carbon utilization enzymes and consequently suppress their translation.[6]

See also

Notes and References

  1. Book: Ramos, Juan-Luis. Virulence and Gene Regulation. 2004-06-17. Springer Science & Business Media. 978-0-306-48376-9. en.
  2. Sonnleitner E, Bläsi U . Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa carbon catabolite repression . PLOS Genetics . 10 . 6 . e1004440 . June 2014 . 24945892 . 4063720 . 10.1371/journal.pgen.1004440 . free .
  3. O'Toole. GA. Gibbs. KA. Hager. PW. Phibbs. PV jr. Kolter. R. The global carbon metabolism regulator Crc is a component of a signal transduction pathway required for biofilm development by Pseudomonas aeruginosa.. J Bacteriol. 2000. 182. 2. 425–431. 10.1128/jb.182.2.425-431.2000. 10629189. 94292.
  4. Zhang L, Chiang WC, Gao Q, Givskov M, Tolker-Nielsen T, Yang L, Zhang G . The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms . Microbiology . 158 . Pt 12 . 3014–9 . December 2012 . 23023972 . 10.1099/mic.0.061192-0 .
  5. Yeung AT, Bains M, Hancock RE . The sensor kinase CbrA is a global regulator that modulates metabolism, virulence, and antibiotic resistance in Pseudomonas aeruginosa . Journal of Bacteriology . 193 . 4 . 918–31 . February 2011 . 21169488 . 3028677 . 10.1128/jb.00911-10 .
  6. Sonnleitner E, Bläsi U . Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa carbon catabolite repression . PLOS Genetics . 10 . 6 . e1004440 . June 2014 . 24945892 . 4063720 . 10.1371/journal.pgen.1004440 . free .

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