| Cow Creek | |
| Name Other: | Big Cow Creek |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | Kansas |
| Subdivision Type3: | Region |
| Subdivision Name3: | Great Plains |
| Subdivision Type5: | City |
| Subdivision Name5: | Hutchinson, KS |
| Length Mi: | 112 |
| Length Ref: | , East |
| Discharge1 Location: | Hutchinson |
| Discharge1 Avg: | 1230cuft/s |
| Source1 Location: | Near Beaver, KS, Great Plains, Kansas, United States |
| Source1 Coordinates: | 38.6436°N -98.6528°W[1] |
| Source1 Elevation: | 1483feet |
| Mouth: | Arkansas River |
| Mouth Location: | Hutchinson, Kansas, United States |
| Mouth Coordinates: | 37.9797°N -97.84°W |
| Mouth Elevation: | 452feet |
| River System: | Arkansas River watershed |
| Basin Size Mi2: | 859.5 |
| Basin Size Ref: | [2] |
Cow Creek is a 112adj=midNaNadj=mid[3] stream that flows through Rice and Reno Counties, Kansas. Cow Creek is a tributary of the Arkansas River; its confluence with the Arkansas is about ten miles southeast of Hutchinson, Kansas.
In the 1850s, Buffalo Bill Mathewson ran a trading post (known as "Buffalo Bill's Well") where the Santa Fe Trail crossed Cow Creek.[4] From Lyons, Kansas, the well is located four miles west and one mile south.