| State: | FL |
| Type: | SR |
| Route: | 59 |
| Maint: | FDOT |
| Map Custom: | yes |
| Length Mi: | 25.919 |
| Length Round: | 3 |
| Direction A: | South |
| Terminus A: | east of Newport |
| Junction: | north of Wacissa north of Lloyd |
| Direction B: | North |
| Terminus B: | north of Lloyd |
| Counties: | Jefferson, Leon |
| Previous Type: | SR |
| Previous Route: | 57 |
| Next Type: | SR |
| Next Route: | 60 |
State Road 59 (SR 59) runs north to south through the eastern Florida Panhandle, with a northern terminus at US 90 near Lloyd, one major intersection at Interstate 10 at exit 217, and a southern terminus at US 98 in rural Jefferson County.
The route is extended at both ends by county roads; to the north through Leon County to the Georgia state line, where it becomes State Route 122 to Thomasville; and on the south via County Road 59, a former secondary state route, into the Saint Marks National Wildlife Refuge.