Cottonwood Branch or Cottonwood Creek is a stream in Henry County in the U.S. state of Missouri. It is a tributary of Honey Creek.
The stream headwaters arise at 38.5067°N -93.7683°W just west of Missouri Route 13 north of Quarles and it flows west-southwest crossing under Missouri Route N north of Huntingdale to its confluence with Honey Creek in an old mined area at 38.4683°N -93.8619°W at an elevation of 732feet.[1]
Cottonwood Branch was so named due to the presence of cottonwood timber along its banks.[2]