Corynebacterium glutamicum explained

Corynebacterium glutamicum is a Gram-positive, rod-shaped bacterium that is used industrially for large-scale production of amino acids, especially glutamic acid and lysine.^[1] While originally identified in a screen for organisms secreting L-glutamate, mutants of C. glutamicum have also been identified that produce various other amino acids and derivatives of amino acids.^[2]

Due to its industrial importance, several clones of C. glutamicum have been sequenced by both industry and academic groups. Furthermore, small RNA data was obtained by RNA-Seq in C. glutamicum ATCC 13032.^[3] The metabolism of this strain has been reconstructed and is available in the form of a genome-scale metabolic model.^[4]

See also

• List of sequenced bacterial genomes

External links

• Genome sequence for C. glutamicum from NCBI.
• Type strain of Corynebacterium glutamicum at BacDive - the Bacterial Diversity Metadatabase

Notes and References

1. Kalinowski, J . Bathe, B . Bartels, D . Bischoff, N . Bott, M . Journal of Biotechnology . 104 . 1–3 . 4 September 2003 . 5–25 . The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of l-aspartate-derived amino acids and vitamins . 12948626 . 10.1016/S0168-1656(03)00154-8 . 3.
2. Zahoor A . Lindner SN . Wendisch VF . Metabolic Engineering of Corynebacterium glutamicum Aimed at Alternative Carbon Sources and New Products . Computational and Structural Biotechnology Journal . 3 . 4 . October 2012 . e201210004 . 24688664 . 10.5936/csbj.201210004 . 3962153.
3. Mentz. Almut. Neshat. Armin. Pfeifer-Sancar. Katharina. Pühler. Alfred. Rückert. Christian. Kalinowski. Jörn. 3. 2013-10-19. Comprehensive discovery and characterization of small RNAs in Corynebacterium glutamicum ATCC 13032. BMC Genomics. 14. 1 . 714. 10.1186/1471-2164-14-714. 1471-2164. 4046766. 24138339 . free .
4. Feierabend . Martina. Renz. Alina. Zelle. Elisabeth. Nöh. Katharina. Wiechert. Wolfgang. Dräger . Andreas. 3. High-Quality Genome-Scale Reconstruction of Corynebacterium glutamicum ATCC 13032. 10.3389/fmicb.2021.750206. 34867870. 8634658. 1664-302X. Frontiers in Microbiology. 2021. 10. 3432. 12. free.