Corticotropin-releasing hormone binding protein family explained

Corticotropin-releasing hormone binding protein (CRH-BP) binds corticotropin-releasing hormone (CRH) and several related peptide hormones (urocortin 1, urotensin 1, and sauvagine).[1] It is an ancient, highly conserved protein whose origin predates the divergence of protostomes and deuterostomes.[2]

Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. It is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion, and is a neurotransmitter or neuromodulator at other sites in the central nervous system. In non-mammalian vertebrates, CRH not only acts as a neurotransmitter and hypophysiotropin, it also acts as a potent thyrotropin-releasing factor,[3] allowing CRH to regulate both the adrenal and thyroid axes, especially in development.

Corticotropin-releasing factor binding protein (CRH-BP) is thought to play an inhibitory role in which it binds CRH and other CRH-like ligands and prevents the activation of CRH receptors 1 and 2. There is however evidence that CRH-BP may also exhibit diverse extra and intracellular roles in a cell specific fashion and at specific times in development.[4]

Human proteins

CRHBP

Notes and References

  1. Ketchesin. Kyle D.. Stinnett. Gwen S.. Seasholtz. Audrey F.. 2017-09-03. Corticotropin-releasing hormone-binding protein and stress: from invertebrates to humans. Stress. en. 20. 5. 449–464. 10.1080/10253890.2017.1322575. 28436309. 41347737. 1025-3890. 7885796.
  2. Huising. Mark O.. Flik. Gert. May 2005. The Remarkable Conservation of Corticotropin-Releasing Hormone (CRH)-Binding Protein in the Honeybee (Apis mellifera) Dates the CRH System to a Common Ancestor of Insects and Vertebrates. Endocrinology. en. 146. 5. 2165–2170. 10.1210/en.2004-1514. 15718273. 0013-7227. free. 2066/33202. free.
  3. De Groef. Bert. Van der Geyten. Serge. Darras. Veerle M.. Kühn. Eduard R.. March 2006. Role of corticotropin-releasing hormone as a thyrotropin-releasing factor in non-mammalian vertebrates. General and Comparative Endocrinology. en. 146. 1. 62–68. 10.1016/j.ygcen.2005.10.014. 16337947.
  4. Seasholtz AF, Valverde RA, Denver RJ . Corticotropin-releasing hormone-binding protein: biochemistry and function from fishes to mammals . J. Endocrinol. . 175 . 1 . 89–97 . 2002 . 12379493 . 10.1677/joe.0.1750089. free .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Corticotropin-releasing hormone binding protein family".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.