CorA metal ion transporter explained

The CorA transport system is the primary Mg²⁺ influx system of Salmonella typhimurium and Escherichia coli.^{[1] [2]} CorA is ubiquitous in the Bacteria and Archaea. There are also eukaryotic members of the family localized to the mitochondrial membrane such as MRS2 and Lpe10 in yeast.

Subfamilies

• Magnesium and cobalt transport protein CorA

Human proteins containing this domain

MRS2L

Further reading

• Kehres DG, Lawyer CH, Maguire ME . The CorA magnesium transporter gene family . Microb. Comp. Genom. . 3 . 3 . 151–69 . 1998 . 9775386 . 10.1089/omi.1.1998.3.151.
• Smith RL, Szegedy MA, Kucharski LM . The CorA Mg2+ transport protein of Salmonella typhimurium. Mutagenesis of conserved residues in the third membrane domain identifies a Mg2+ pore . J. Biol. Chem. . 273 . 44 . 28663–9 . October 1998 . 9786860 . 10.1074/jbc.273.44.28663. etal. free .
• Wiesenberger G, Waldherr M, Schweyen RJ . The nuclear gene MRS2 is essential for the excision of group II introns from yeast mitochondrial transcripts in vivo . J. Biol. Chem. . 267 . 10 . 6963–9 . April 1992 . 10.1016/S0021-9258(19)50522-1 . 1551905 . free .

Notes and References

1. Maguire ME, Kehres DG, Lawyer CH . The CorA magnesium transporter gene family . Microb. Comp. Genom. . 3 . 3 . 151–169 . 1998 . 9775386 . 10.1089/omi.1.1998.3.151.
2. Smith RL, Maguire ME, Szegedy MA, Kucharski LM, Walker C, Wiet RM, Redpath A, Kaczmarek MT . The CorA Mg2+ transport protein of Salmonella typhimurium. Mutagenesis of conserved residues in the third membrane domain identifies a Mg2+ pore . J. Biol. Chem. . 273 . 44 . 28663–28669 . 1998 . 9786860 . 10.1074/jbc.273.44.28663. free .