Copper ibuprofenate explained

Copper ibuprofenate is a chemical complex consisting of copper(II) and the chelate form of the anti-inflammatory drug ibuprofen.^{[1] [2]} The compound is prepared by the reaction of sodium ibuprofenate with copper(II) sulfate.

It has been suggested that copper complexes of anti-inflammatory drugs are more active than the parent drug^[3] and produce fewer gastrointestinal side-effects.^[4] In 2008, a United States patent was issued for the utilization of ibuprofenate complexes (including copper ibuprofenate) as a wood preservative.

Further reading

• A. Latif . Abuhijleh. 1997. Synthesis and characterization of copper-ibuprofenate complexes with 2,2'-bipyridine and 1,10-phenanthrolines and their hydrolytic activities in phosphate diester cleavage. Polyhedron. 16. 4. 733–740. 10.1016/0277-5387(96)00214-8.

Notes and References

1. Frazier. D. R. . S. K. Lynch . G. O. Carlisle. 1981. Synthesis and magnetic properties of bis[2-(4-isobutylphenyl)propionato]copper(II) . Journal of Inorganic and Nuclear Chemistry. 43. 11. 2747–2748 . 10.1016/0022-1902(81)80610-0.
2. Abuhijleh AL . Mononuclear and binuclear copper(II) complexes of the antiinflammatory drug ibuprofen: synthesis, characterization, and catecholase-mimetic activity . J. Inorg. Biochem. . 55 . 4 . 255–62 . September 1994 . 7964714 . 10.1016/0162-0134(94)85010-0.
3. Sorenson JR . Copper complexes offer a physiological approach to treatment of chronic diseases . Prog Med Chem . Progress in Medicinal Chemistry . 26 . 437–568 . 1989 . 2690187 . 10.1016/s0079-6468(08)70246-7. 9780444810380 .
4. Gordijo CR, Barbosa CA, Da Costa Ferreira AM, Constantino VR, de Oliveira Silva D . Immobilization of ibuprofen and copper-ibuprofen drugs on layered double hydroxides . J Pharm Sci . 94 . 5 . 1135–48 . May 2005 . 15793807 . 10.1002/jps.20336 .