| Coppa Italia | |
| Year: | 2005–06 |
| Country: | Italy |
| Num Teams: | 72 |
| Champions: | Internazionale |
| Count: | 5 |
| Runner-Up: | Roma |
| Matches: | 86 |
| Goals: | 193 |
| Top Goal Scorer: | Alessandro Del Piero (5 goals) |
| Prevseason: | 2004–05 |
| Nextseason: | 2006–07 |
The 2005–06 Coppa Italia was the 59th edition of the national domestic tournament. For the second consecutive season, Roma and Internazionale were the finalists. Inter won the tournament by a score of 4–1 aggregate in the final. It began on August 7, 2005 and ended on May 11, 2006.
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See main article: 2006 Coppa Italia final.
Internazionale won 4–2 on aggregate.
| Rank | Player | Club | Goals | |
|---|---|---|---|---|
| 1 |  Alessandro Del Piero | Juventus | 5 | |
| 2 |  Mariano González | Palermo | 4 |