Copalyl diphosphate synthase explained
| copalyl diphosphate synthase |
| Ec Number: | 5.5.1.12 |
| Cas Number: | 157972-08-2 |
| Go Code: | 0050559 |
In enzymology, a copalyl diphosphate synthase is an enzyme that catalyzes the chemical reaction
geranylgeranyl diphosphate
(+)-copalyl diphosphate
Hence, this enzyme has one substrate, geranylgeranyl diphosphate, and one product, (+)-copalyl diphosphate.
This enzyme belongs to the family of isomerases, specifically the class of intramolecular lyases. The systematic name of this enzyme class is (+)-copalyl-diphosphate lyase (decyclizing). This enzyme participates in diterpenoid biosynthesis.
References
- RB . 2000 . Abietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the "pseudomature" recombinant enzyme . Biochemistry . 39 . 15592 - 602 . 11112547 . 10.1021/bi001997l . Flory . JE . Jetter . R . Ravn . MM . Lee . HJ . Coates . RM . Croteau . RB . 50 .
- Peters RJ, Ravn MM, Coates RM, Croteau RB . 2001 . Bifunctional abietadiene synthase: free diffusive transfer of the (+)-copalyl diphosphate intermediate between two distinct active sites . J. Am. Chem. Soc. . 123 . 8974 - 8 . 11552804 . 10.1021/ja010670k . 37 .
- Peters RJ, Croteau RB . 2002 . Abietadiene synthase catalysis: mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement . Proc. Natl. Acad. Sci. U.S.A. . 99 . 580 - 4 . 11805316 . 10.1073/pnas.022627099 . 2 . 117348 . 2002PNAS...99..580P . free .
- Ravn MM, Peters RJ, Coates RM, Croteau R . 2002 . Mechanism of abietadiene synthase catalysis: stereochemistry and stabilization of the cryptic pimarenyl carbocation intermediates . J. Am. Chem. Soc. . 124 . 6998 - 7006 . 12059223 . 10.1021/ja017734b . 24 .
- Peters RJ, Croteau RB . 2002 . Abietadiene synthase catalysis: conserved residues involved in protonation-initiated cyclization of geranylgeranyl diphosphate to (+)-copalyl diphosphate . Biochemistry . 41 . 1836 - 42 . 11827528 . 10.1021/bi011879d . 6 .
