The Copa San Isidro de Curuguaty (English: San Isidro de Curuguaty Cup) is a football (soccer) tournament of regional character played between the champions of the Campeonato Nacional de Interligas organized by the Unión del Fútbol del Interior (Paraguay) and the Copa Nacional de Selecciones del Interior organized by the Organización del Fútbol del Interior (Uruguay).
The tournament was created by Eusebio Baeza, former executive of Pluna and the Asociación Uruguaya de Fútbol, and Arturo Filartiga Candia, member of the Asociación Paraguaya de Fútbol. The tournament is played every two years since 1978 with home and away games. If teams tie in points and goals the game is decided by penalty kicks.
| Year | Winner | Runners-up | Aggregate | 1st leg | 2nd leg | |
|---|---|---|---|---|---|---|
| 1956 | Trinidad | Liga Central | 4-2 | 2-1 | 2-1 | |
| 1959 | Fray Bentos | Villeta | 7-1 | 3-0 | 4-1 | |
| 1963 | Colonia | Ypacaraí | 3-3 | 0-1 | 3-2 | |
| 1966 | Tacuarembó | Coronel Oviedo | 4-1 | 2-0 | 2-1 | |
| 1978 | Federación Misionera | Melo | 4-0 | 1-0 | 3-0 | |
| 1980 | Federación Misionera | Tacuarembó | 5-5 | 2-1 | 3-4 | |
| 1982 | Maldonado | Villarrica | 1-1 | 1-0 | 0-1 | |
| 1984 | San Pedro | Rocha | 4-3 | 1-3 | 3-0 | |
| 1988 | Paysandú | Paranaense | 4-3 | 1-2 | 3-1 | |
| 1990 | Ypacaraí | Florida | 2-1 | 1-0 | 1-1 | |
| 1992 | Liga del Sud | Minas | 6-1 | 2-0 | 4-1 | |
| 1994 | Maldonado | Caaguazú | 9-2 | 4-0 | 5-2 | |
| 1996 | Paranaense | Maldonado Interior | 3-3 | 2-2 | 1-1 | |
| 1998 | Itauguá | Melo | 4-3 | 1-1 | 3-2 | |
| 2000 | San José Liga Mayor | Carapeguá | 2-2 | 1-1 | 1-1 | |
| 2002 | Limpio | Durazno | 5-4 | 5-4 | 0-0 | |
| 2004 | San José de los Arroyos | Durazno | 4-3 | 0-2 | 4-1 | |
| 2006 | Pirayú | Maldonado Liga Mayor | 3-3 | 1-2 | 2-1 | |
| 2008 | Colonia Departamental | Caaguazú | 4-2 | 3-1 | 1-1 | |
| 2010 | Liga Caacupeña | Artigas | 3-1 | 1-1 | 2-0 | |
| 2012 | Liga Paranaense | Colonia | 3-2 | 1-1 | 2-1 | |
| 2014 | Liberación | Tacuarembó | 1-1 (a) | 0-0 | 1-1 | |
| 2016 | Liga Guaireña | Nueva Palmira | 4-2 | 3-1 | 1-1 | |
| 2018 | Liga Atyreña | Durazno | 3-3 | 2-1 | 1-2 | |
| 2023 | Lavalleja | Liga Encarnacena | 4-4 | 2-1 | 2-3 |
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