| Tourney Name: | Copa Mercosur |
| Year: | 2001 |
| Dates: | 21 July 2001 – 24 January 2002 |
| Num Teams: | 20 |
| Associations: | 5 |
| Champion Other: |  San Lorenzo |
| Count: | 1 |
| Second Other: |  Flamengo |
| Matches: | 73 |
| Goals: | 197 |
| Top Scorer: | Bernardo Romeo (10 goals) |
| Prevseason: | 2000 |
The Copa Mercosur 2001 was the 4th and final staging of the international club cup.
The competition started on 21 July 2001 and concluded on 24 January 2002 with San Lorenzo beating Flamengo in the final.[1]
| width=125 | Country | width=150 | Team |
|---|---|---|---|
| Argentina (6 berths) | Boca Juniors | ||
| Independiente | |||
| River Plate | |||
| San Lorenzo | |||
| Talleres | |||
| Vélez Sársfield | |||
(7 berths) | Corinthians | ||
| Cruzeiro | |||
| Flamengo | |||
| Grêmio | |||
| Palmeiras | |||
| São Paulo | |||
| Vasco da Gama | |||
(3 berths) | Colo-Colo | ||
| Universidad Católica | |||
| Universidad de Chile | |||
 Paraguay(2 berths) | Cerro Porteño | ||
| Olimpia | |||
(2 berths) | Nacional | ||
| Peñarol | |||
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The three best second-place teams from the five groups advanced to the quarterfinals along with the five group winners.
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Flamengo won 4–0 on aggregate.----Corinthians won 3–2 on aggregate.----San Lorenzo won 6–3 on aggregate.----Gremio won 2–0 on aggregate.
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San Lorenzo won 5–3 on aggregate.----2–2 on aggregate, Flamengo won 4–2 on penalties
See main article: 2001 Copa Mercosur Finals.
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Originally scheduled for Dec 19 but postponed to January 24, 2002 due to social unrest in Argentina
1–1 on aggregate, San Lorenzo won 4–3 on penalties