CopA-like RNA explained

CopA-like RNA
Symbol:	CopA
Rfam:	RF00042
Rna Type:	Gene antisense
Tax Domain:	Bacteria

CopA-like RNA is a family of non-coding RNAs found on the R1 plasmid.

In several groups of bacterial plasmids, antisense RNAs regulate copy number through inhibition of replication initiator protein synthesis. These RNAs are characterised by a long hairpin structure interrupted by several unpaired nucleotides or bulged loops. In plasmid R1, the inhibitory complex between the antisense RNA (CopA) and its target mRNA (CopT) is characterised by a four-way junction structure and a side-by-side helical alignment.^{[1] [2] [3]}

See also

Plasmid-mediated resistance (sRNA section)

Notes and References

1. Nordgren . S . Slagter-Jager JG. Wagner GH . 2001 . Real time kinetic studies of the interaction between folded antisense and target RNAs using surface plasmon resonance . J Mol Biol . 310 . 1125–1134 . 11502000 . 10.1006/jmbi.2001.4802 . 5.
2. 10.1093/nar/14.6.2523 . Gerhart E, Wagner H, Nordström K . Structural analysis of an RNA molecule involved in replication control of plasmid R1. . Nucleic Acids Res . 14 . 6 . 2523–2538 . 1986 . 2421250 . 339680.
3. Jelloul N, Bouzouita H, Belkahia A . [Significance of impedance tests in childhood deafness]. . Tunis Med . 57 . 4–5 . 236–240 . 1979. 555093.