| Official Name: | Cook, Ohio |
| Settlement Type: | Unincorporated community |
| Mapsize: | 250px |
| Pushpin Map: | Ohio#USA |
| Pushpin Label: | Cook |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Ohio |
| Subdivision Type2: | Counties |
| Subdivision Name2: | Fayette |
| Subdivision Type3: | Township |
| Subdivision Name3: | Madison |
| Unit Pref: | Imperial |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Elevation Ft: | 912 |
| Coordinates: | 39.6831°N -83.3072°W |
| Postal Code Type: | ZIP code |
| Postal Code: | 43143 |
| Area Code: | 740 |
| Blank Name: | GNIS feature ID |
| Blank Info: | 1070722 |
Cook is an unincorporated community in Madison Township, Fayette County, Ohio, United States. It is located along Cook-Yankeetown Road (Fayette County Highway 34), just west of its intersection with U.S. Route 62/State Route 3.[1]
The community is named after Matthew S. Cook, the original owner of the town site, who gave the right of way to the Baltimore and Ohio Railroad.[2] The Cook Post Office was established on January 20, 1885, but closed on March 31, 1933. The mail service is now sent through the Mount Sterling branch.