Paul J. Tesar Explained

Paul J. Tesar
Birth Place:Cleveland, Ohio, US

Paul J. Tesar is an American developmental biologist. He is the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics at Case Western Reserve University School of Medicine. His research is focused on regenerative medicine.

Early life and education

Tesar was born in Cleveland, Ohio.[1] He graduated with a BSc in biology from Case Western Reserve University in 2003. As part of the National Institutes of Health Oxford-Cambridge Scholar Program, he earned a PhD in 2007.[2]

Career

While a graduate student, Tesar published a paper describing epiblast-derived stem cells, a new type of pluripotent stem cell, research for which he received both the Beddington Medal of the British Society for Developmental Biology[3] and the Harold M. Weintraub Award of the Fred Hutchinson Cancer Research Center.[4]

In 2010 he returned to Case Western Reserve University School of Medicine to teach.[5] In 2014 he was appointed to the Dr. Donald and Ruth Weber Goodman chair in innovative therapeutics.[6]

Research

Tesar developed methods to generate and grow oligodendrocytes and oligodendrocyte progenitor cells (OPCs) from pluripotent stem cells and skin cells.[7] [8] He also made human brain organoids containing human myelin, called oligocortical spheroids.[9] [10] Tesar identified drugs that stimulate myelin regeneration and reverse paralysis in mice with multiple sclerosis.[11] Tesar also identified CRISPR and antisense oligonucleotide therapeutics that restored myelination and extended the lifespan of mice with Pelizaeus–Merzbacher disease.[12] [13] [14]

Awards

Notes and References

  1. News: The BriefCase. September 17, 2004. The Observer.
  2. Web site: Tesar '03 Continues to Excel – International Biomedical Alliance. January 18, 2020. May 22, 2022. https://web.archive.org/web/20220522164641/https://biomedalliance.org/2018/08/07/tesar-03-continues-to-excel/. dead.
  3. Web site: The Beddington Medal. BSDB - British Society for Developmental Biology. live. https://web.archive.org/web/20140103075449/http://bsdb.org/awards/the-beddington-medal/. January 3, 2014.
  4. Web site: Paul Tesar – International Biomedical Alliance. November 20, 2019. May 22, 2022. https://web.archive.org/web/20220522164130/https://biomedalliance.org/project/paul-tesar/. dead.
  5. Web site: School of Medicine faculty member receives prestigious award for stem cell research. February 5, 2015. The Daily. live. https://web.archive.org/web/20191204202851/https://thedaily.case.edu/school-of-medicine-faculty-member-receives-prestigious-award-for-stem-cell-research/. December 4, 2019.
  6. Web site: More efficiently generating brain stem cells: Technique improves understanding of myelin disease. ScienceDaily. November 1, 2019. https://web.archive.org/web/20191101184942/https://www.sciencedaily.com/releases/2018/10/181001130334.htm. November 1, 2019. live.
  7. Web site: Study: New process converts skin cells into brain cells. April 15, 2013 . CBS News. live. https://web.archive.org/web/20191101184942/https://www.cbsnews.com/news/study-new-process-converts-skin-cells-into-brain-cells/. November 1, 2019.
  8. Web site: Ordinary skin cells morphed into functional brain cells. ScienceDaily. live. https://web.archive.org/web/20150906055334/http://www.sciencedaily.com/releases/2013/04/130414193143.htm. September 6, 2015.
  9. Madhavan M, Nevin ZS, Shick HE, Garrison E, et al. . September 2018. Induction of myelinating oligodendrocytes in human cortical spheroids. Nature Methods. 15. 9. 700–06. 10.1038/s41592-018-0081-4. 30046099. 6508550. 1548-7105.
  10. Web site: New method adds missing functionality to brain organoids: Protocol adds a new cell type enabling myelination in human 'mini-brains' for laboratory research. ScienceDaily. live. https://web.archive.org/web/20191101184943/https://www.sciencedaily.com/releases/2018/07/180726085756.htm. November 1, 2019.
  11. Web site: Drugs stimulate body's own stem cells to replace the brain cells lost in multiple sclerosis. ScienceDaily. live. https://web.archive.org/web/20160112200012/http://www.sciencedaily.com/releases/2015/04/150420111357.htm. January 12, 2016.
  12. Elitt. Matthew S.. Barbar. Lilianne. Shick. H. Elizabeth. Powers. Berit E.. Maeno-Hikichi. Yuka. Madhavan. Mayur. Allan. Kevin C.. Nawash. Baraa S.. Nevin. Zachary S.. Olsen. Hannah E.. Hitomi. Midori. December 31, 2018. Therapeutic suppression of proteolipid protein rescues Pelizaeus-Merzbacher Disease in mice. bioRxiv. 508192. 10.1101/508192. free. November 23, 2019. https://web.archive.org/web/20191026203912/https://www.biorxiv.org/content/10.1101/508192v1. October 26, 2019. live.
  13. Web site: 1 July 2020. Research finds new approach to treating certain neurological diseases. 1 July 2020. MedicalXpress. Their research was published online July 1 in the journal Nature. "The pre-clinical results were profound. PMD mouse models that typically die within a few weeks of birth were able to live a full lifespan after treatment," said Paul Tesar.
  14. Elitt. Matthew S.. Barbar. Lilianne. Shick. H. Elizabeth. Powers. Berit E.. Maeno-Hikichi. Yuka. Madhavan. Mayur. Allan. Kevin C.. Nawash. Baraa S.. Gevorgyan. Artur S.. Hung. Stevephen. Nevin. Zachary S.. 2020-07-01. Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease. Nature. 585. 7825. en. 397–403. 10.1038/s41586-020-2494-3. 32610343. 1476-4687. 7810164. 2020Natur.585..397E.
  15. Web site: Harold M. Weintraub Awardees from 2001-2014. November 1, 2019. https://web.archive.org/web/20191101154515/https://www.fredhutch.org/content/dam/www/research/divisions/basic-sciences/weintraub-award/WGSA_Archive.pdf. November 1, 2019. live.
  16. Web site: NYSCF - Robertson Investigator Wins International Stem Cell Award. November 1, 2019. https://web.archive.org/web/20191101154518/https://nyscf.org/resources/nyscf-robertson-investigator-wins-international-stem-cell-award/. November 1, 2019. live.
  17. Web site: The ISSCR Announces 2015 Recipients of the McEwen Award for Innovation, the ISSCR-BD Biosciences Outstanding Young Investigator, and the ISSCR Public Service Awards, 20 January, 2015. isscr.org.
  18. Web site: Senior Members List. 24 June 2022. National Academy of Inventors.

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