Conopharyngine Explained

Conopharyngine should not be confused with Conopharyngia elegans.

Conopharyngine is the major alkaloid present in the leaves and stem-bark of Tabernaemontana pachysiphon and Conopharyngia durissima.^{[1] [2] [3]} It is closely related voacangine and coronaridine. Conopharyngine pseudoindoxyl, a derivative of it, is also found in the same plant Tabernaemontana pachysiphon.^[4]

Pharmacology

It possess central nervous system stimulant activity and produces bradycardia and hypotension in cats. It has weak acetylcholinesterase inhibitory activity and significantly increases hexobarbitone induced sleeping time.^[5]

Toxicity

It has low intravenous toxicity in mice (LD₅₀ = 143 mg/kg).

See also

• Ibogaline

Notes and References

1. Web site: Tabernaemontana pachysiphon.
2. van Beek TA, de Smidt C, Verpoorte R . Phytochemical investigation of Tabernaemontana crassa . . 14 . 2–3 . 315–8 . 1985 . 4094474 . 10.1016/0378-8741(85)90096-0 .
3. Renner. U.. Prins. D. A.. Stoll. W. G.. Alkaloide ausConopharyngia durissima STAPF Isovoacangin, Conopharyngin, Conodurin und Conoduramin. Helvetica Chimica Acta. 42. 5. 1959. 1572–1581. 0018-019X. 10.1002/hlca.19590420519.
4. Crooks PA, Robinson B . Conopharyngine pseudoindoxyl, a new alkaloid from Tabernamontana pachysiphon Stapf. var cumminsii (Stapf.) H. Huber . . 25 . 10 . 820–3 . October 1973 . 4149744 . 10.1111/j.2042-7158.1973.tb09948.x . 9261649 .
5. Carroll PR, Starmer GA . Studies on the pharmacology of conopharyngine, an indole alkaloid of the voacanga series . . 30 . 1 . 173–85 . May 1967 . 6039971 . 1557242 . 10.1111/j.1476-5381.1967.tb02123.x .