Conjugated oligoelectrolytes explained

Conjugated oligoelectrolytes, or COEs, are a class of synthetic antimicrobials designed to prevent and circumvent antimicrobial resistance via different mechanism of action than traditional antibiotics.^{[1] [2]} COEs insert into cell membranes and can function as electron transporters, but were found to inhibit bacterial growth. They can also be used for tracking the progress of tumor growth.^[3]

Notes and References

1. Heithoff . Douglas M. . Mahan . Scott P. . Barnes V . Lucien . Leyn . Semen A. . George . Cyril X. . Zlamal . Jaime E. . Limwongyut . Jakkarin . Bazan . Guillermo C. . Fried . Jeffrey C. . Fitzgibbons . Lynn N. . House . John K. . Samuel . Charles E. . Osterman . Andrei L. . Low . David A. . Mahan . Michael J. . A broad-spectrum synthetic antibiotic that does not evoke bacterial resistance . eBioMedicine . February 2023 . 104461 . 10.1016/j.ebiom.2023.104461. free .
2. Tiihonen . Armi . Cox-Vazquez . Sarah J. . Liang . Qiaohao . Ragab . Mohamed . Ren . Zekun . Hartono . Noor Titan Putri . Liu . Zhe . Sun . Shijing . Zhou . Cheng . Incandela . Nathan C. . Limwongyut . Jakkarin . Moreland . Alex S. . Jayavelu . Senthilnath . Bazan . Guillermo C. . Buonassisi . Tonio . Predicting Antimicrobial Activity of Conjugated Oligoelectrolyte Molecules via Machine Learning . Journal of the American Chemical Society . 17 November 2021 . 143 . 45 . 18917–18931 . 10.1021/jacs.1c05055. 2105.10236 .
3. Zhou . Cheng . Li . Zeshun . Zhu . Ziyue . Chia . Geraldine W. N. . Mikhailovsky . Alexander . Vázquez . Ricardo Javier . Chan . Samuel J. W. . Li . Kai . Liu . Bin . Bazan . Guillermo C. . Conjugated Oligoelectrolytes for Long‐Term Tumor Tracking with Incremental NIR‐II Emission . Advanced Materials . May 2022 . 34 . 20 . 2201989 . 10.1002/adma.202201989.