Congenital hemolytic anemia explained

Congenital hemolytic anemia
Synonyms:Hereditary hemolytic anemia
Field:Hematology

Congenital hemolytic anemia (CHA) is a diverse group of rare hereditary conditions marked by decreased life expectancy and premature removal of erythrocytes from blood flow. Defects in erythrocyte membrane proteins and red cell enzyme metabolism, as well as changes at the level of erythrocyte precursors, lead to impaired bone marrow erythropoiesis. CAH is distinguished by variable anemia, chronic extravascular hemolysis, decreased erythrocyte life span, splenomegaly, jaundice, biliary lithiasis, and iron overload. Immune-mediated mechanisms may play a role in the pathogenesis of these uncommon diseases, despite the paucity of data regarding the immune system's involvement in CHAs.[1]

Diagnosis

Hereditary spherocytosis

See main article: Hereditary spherocytosis. Hereditary spherocytosis is a common hemolytic disorder distinguished by a defect or deficiency within one or more of the proteins that make up the membrane of the red blood cell. As a result of this, red blood cells have an abnormal shape, require more metabolic energy, and are trapped and destroyed prematurely in the spleen. With a prevalence of about 1 in 2000, hereditary spherocytosis, including the very mild or subclinical forms, is the most prevalent cause of non-immune hemolytic anemia in people of Northern European ancestry. However, very mild varieties of the disease are likely to be far more common. In 75% of cases, hereditary spherocytosis is inherited as a dominant trait, with the remainder being truly recessive cases as well as de novo mutations.[2] The hallmark of HS is chronic hemolysis. Most people have a mild condition that does not require any treatment. In extreme situations, it causes jaundice, splenomegaly, and severe anemia.[3] Folate supplementation is advised in cases of severe and moderate HS but is not required in cases of mild HS.[4] In severe cases, splenectomy may be advised as a therapy and may help to improve the condition.[3]

Hereditary elliptocytosis

See main article: Hereditary elliptocytosis. Hereditary elliptocytosis is a group of red blood cell membrane disorders characterized by elliptical erythrocytes and decreased RBC survival. Defects in the cytoskeletal proteins that keep red blood cells in their biconcave shape can cause hereditary elliptocytosis. These defects can be either in quantity or structure. Since most patients have compensated hemolysis even in the presence of hemolysis, symptoms are generally uncommon. Patients with significant clinical hemolysis, on the other hand, may experience anemia-related symptoms. Hereditary elliptocytosis is diagnosed by identifying abnormal red blood cell morphology on a peripheral blood smear and identifying characteristic membrane biomechanical properties with osmotic gradient ektacytometry. Hereditary elliptocytosis (HE) rarely causes symptoms and requires no treatment. Splenectomy significantly improves the condition of patients with clinically significant hemolytic anemia.[5]

Glucose-6-phosphate dehydrogenase deficiency

See main article: Glucose-6-phosphate dehydrogenase deficiency. Glucose-6-phosphate dehydrogenase deficiency is the most common enzyme deficiency worldwide,[6] is an inborn error of metabolism that predisposes to red blood cell breakdown.[7] Most of the time, those who are affected have no symptoms.[8] Following a specific trigger, symptoms such as yellowish skin, dark urine, shortness of breath, and feeling tired may develop.[7] [9] Complications can include anemia and newborn jaundice.[9] The most important measure is prevention – avoidance of the drugs and foods that cause hemolysis. Vaccination against some common pathogens (e.g. hepatitis A and hepatitis B) may prevent infection-induced attacks.[10]

Pyruvate kinase deficiency

See main article: Pyruvate kinase deficiency. Pyruvate kinase deficiency is an inherited metabolic disorder of the enzyme pyruvate kinase which affects the survival of red blood cells.[11] [12] Both autosomal dominant and recessive inheritance have been observed with the disorder; classically, and more commonly, the inheritance is autosomal recessive. Pyruvate kinase deficiency is the second most common cause of enzyme-deficient hemolytic anemia, following G6PD deficiency.[13] The symptoms of pyruvate kinase deficiency are mild to severe hemolytic Anemia, cholecystolithiasis, tachycardia, hemochromatosis, icteric sclera, splenomegaly, leg ulcers, jaundice, fatigue, and shortness of breath.[14] The diagnosis of pyruvate kinase deficiency can be done by full blood counts (differential blood counts) and reticulocyte counts.[15] The most common treatment is blood transfusions, especially in infants and young children. This is done if the red blood cell count has fallen to a critical level.[16]

Aldolase A deficiency

See main article: Aldolase A deficiency. Aldolase A deficiency is an autosomal recessive metabolic disorder resulting in a deficiency of the enzyme aldolase A; the enzyme is found predominantly in red blood cells and muscle tissue. The deficiency may lead to hemolytic anaemia as well as myopathy associated with exercise intolerance and rhabdomyolysis in some cases.[17]

Sickle cell anemia

See also: Sickle cell disease. The underlying cause of sickle cell anemia is the synthesis of aberrant hemoglobin, which attaches to other aberrant hemoglobin molecules inside the red blood cell to undergo rigid deformation.[18] Sickle cell anemia symptoms usually appear around the age of six months. They can change over time and differ from person to person. A few indications and symptoms include anemia, sporadic episodes of excruciating pain, hand and foot edema, recurrent infections, delayed puberty or growth, and visual issues.[19] The goal of sickle cell anemia treatment is usually to avoid pain episodes, relieve symptoms, and prevent complications. Medication and blood transfusions may be used as treatments. A stem cell transplant may be able to cure the disease in some children and teenagers. The use of hydroxyurea on a daily basis decreases the frequency of painful crises and may reduce the demand for blood transfusions and hospitalizations.[20]

Congenital dyserythropoietic anemia

See main article: Congenital dyserythropoietic anemia. Congenital dyserythropoietic anemia (CDA) is a rare blood disorder, similar to the thalassemias. CDA is one of many types of anemia, characterized by ineffective erythropoiesis, and resulting from a decrease in the number of red blood cells (RBCs) in the body and a less than normal quantity of hemoglobin in the blood. The symptoms and signs of congenital dyserythropoietic anemia are consistent fatigue, weakness, and pale skin.[21] The diagnosis of congenital dyserythropoietic anemia can be done via sequence analysis of the entire coding region, types I,[22] II,[23] III[24] and IV. Treatment of individuals with CDA usually consist of frequent blood transfusions, but this can vary depending on the type that the individual has.[25]

Thalassemia

See main article: Thalassemia. Thalassemia is an inherited blood disorder that results in abnormal hemoglobin.[26] Symptoms depend on the type of thalassemia and can vary from none to severe. Often there is mild to severe anemia (low red blood cells or hemoglobin) as thalassemia can affect the production of red blood cells and also affect how long the red blood cells live. Symptoms of anemia include feeling tired and having pale skin. Other symptoms of thalassemia include bone problems, an enlarged spleen, yellowish skin, pulmonary hypertension, and dark urine. Slow growth may occur in children.[27] Treatment depends on the type and severity. Treatment for those with more severe disease often includes regular blood transfusions, iron chelation, and folic acid. Iron chelation may be done with deferoxamine, deferasirox or deferiprone.[28] Occasionally, a bone marrow transplant may be an option.[29]

See also

Further reading

Notes and References

  1. Zaninoni . Anna . Fermo . Elisa . Vercellati . Cristina . Marcello . Anna Paola . Barcellini . Wilma . Bianchi . Paola . Congenital Hemolytic Anemias: Is There a Role for the Immune System? . Frontiers in Immunology . Frontiers Media SA . 11 . June 23, 2020 . 1309 . 1664-3224 . 10.3389/fimmu.2020.01309 . free. 32655575 . 7324678 .
  2. Iolascon . A. . Avvisati . R.A. . Piscopo . C. . Hereditary spherocytosis . Transfusion Clinique et Biologique . Elsevier BV . 17 . 3 . 2010 . 1246-7820 . 10.1016/j.tracli.2010.05.006 . 138–142. 20655264 .
  3. Shafqat . Shah . Roger . Vega . Hereditary Spherocytosis . Pediatrics in Review . May 2004 . 25 . 5 . 168–172 . 10.1542/pir.25-5-168 . 15121908 . 20 November 2023 . 0191-9601.
  4. Bolton-Maggs . Paula H. B. . Langer . Jacob C. . Iolascon . Achille . Tittensor . Paul . King . May-Jean . Guidelines for the diagnosis and management of hereditary spherocytosis – 2011 update . British Journal of Haematology . Wiley . 156 . 1 . November 5, 2011 . 0007-1048 . 10.1111/j.1365-2141.2011.08921.x . 37–49. free . 22055020 .
  5. Kim . Daniel J . Hereditary Elliptocytosis: Practice Essentials, Pathophysiology, Etiology . Medscape Reference . July 31, 2023 . November 20, 2023.
  6. Frank . Jennifer E. . 2005-10-01 . Diagnosis and Management of G6PD Deficiency . American Family Physician . 72 . 7 . 1277–1282 . 16225031 . 0002-838X.
  7. Web site: Glucose-6-phosphate dehydrogenase deficiency. Genetics Home Reference. 20 November 2023. en. 6 December 2017.
  8. Web site: Glucose-6-phosphate dehydrogenase deficiency. Genetic and Rare Diseases Information Center (GARD). 20 November 2023. en. 2017. 27 April 2021. https://web.archive.org/web/20210427154113/https://rarediseases.info.nih.gov/diseases/6520/glucose-6-phosphate-dehydrogenase-deficiency. dead.
  9. Web site: Glucose-6-Phosphate Dehydrogenase Deficiency. NORD (National Organization for Rare Disorders). 20 November 2023. 2017.
  10. Monga A, Makkar RP, Arora A, Mukhopadhyay S, Gupta AK . Case report: Acute hepatitis E infection with coexistent glucose-6-phosphate dehydrogenase deficiency . Can J Infect Dis . 14 . 4 . 230–1 . July 2003 . 18159462 . 2094938 . 10.1155/2003/913679. free .
  11. Web site: Pyruvate kinase deficiency: MedlinePlus Medical Encyclopedia. www.nlm.nih.gov. 2023-11-20.
  12. Web site: Pyruvate kinase deficiency Disease Overview Genetic and Rare Diseases Information Center (GARD) – an NCATS Program. rarediseases.info.nih.gov. 2023-11-20. 2015-09-05. https://web.archive.org/web/20150905112757/https://rarediseases.info.nih.gov/gard/7514/pyruvate-kinase-deficiency/resources/1. dead.
  13. Gallagher. Patrick G.. Glader. Bertil. 2016-05-01. Diagnosis of Pyruvate Kinase Deficiency. Pediatric Blood & Cancer. en. 63. 5. 771–772. 10.1002/pbc.25922. 26836632. 42964783. 1545-5017.
  14. Web site: Pyruvate Kinase Deficiency Clinical Presentation: History and Physical Examination. emedicine.medscape.com. 2023-11-20.
  15. Book: Disorders, National Organization for Rare. NORD Guide to Rare Disorders. 2003-01-01. Lippincott Williams & Wilkins. 9780781730631. 496. en.
  16. Zanella. A.. Bianchi. P.. Fermo. E.. 2007-06-01. Pyruvate kinase deficiency. Haematologica. en. 92. 6. 721–723. 10.3324/haematol.11469. 17550841. 0390-6078. free.
  17. Kishi H, Mukai T, Hirono A, Fujii H, Miwa S, Hori K. 1987. Human aldolase A deficiency associated with a hemolytic anemia: Thermolabile aldolase due to a single base mutation. Proc. Natl. Acad. Sci.. 84. 23. 8623–7. 2825199. 10.1073/pnas.84.23.8623. 299598. 1987PNAS...84.8623K. free.
  18. Lonergan . Gael J. . Cline . David B. . Abbondanzo . Susan L. . Sickle Cell Anemia . RadioGraphics . Radiological Society of North America (RSNA) . 21 . 4 . 2001 . 0271-5333 . 10.1148/radiographics.21.4.g01jl23971 . 971–994. 11452073 .
  19. Web site: Sickle cell anemia-Sickle cell anemia . Mayo Clinic . March 9, 2022 . November 20, 2023.
  20. Web site: Sickle cell anemia-Sickle cell anemia . Mayo Clinic . March 9, 2022 . November 20, 2023.
  21. Web site: CDA. Genetics Home Reference. 2016-01-25. 2023-11-20.
  22. Web site: Congenital dyserythropoietic anemia, type I — Conditions — GTR — NCBI. www.ncbi.nlm.nih.gov. 2023-11-20.
  23. Web site: Congenital dyserythropoietic anemia, type II — Conditions — GTR — NCBI. www.ncbi.nlm.nih.gov. 2023-11-20.
  24. Web site: Congenital dyserythropoietic anemia, type III — Conditions — GTR — NCBI. www.ncbi.nlm.nih.gov. 2023-11-20.
  25. Book: Wintrobe's Clinical Hematology. Lippincott Williams & Wilkins. 2013-08-29. 994. 9781469846224. en. John P.. Greer. Daniel A.. Arber. Bertil. Glader. Alan F.. List. Robert T.. Means. Frixos. Paraskevas. George M.. Rodgers.
  26. Web site: What Are Thalassemias?. NHLBI. 5 September 2016. 3 July 2012. live. https://web.archive.org/web/20160826182827/http://www.nhlbi.nih.gov/health/health-topics/topics/thalassemia. 26 August 2016.
  27. Web site: What Are the Signs and Symptoms of Thalassemias?. NHLBI. 5 September 2016. 3 July 2012. live. https://web.archive.org/web/20160916112346/http://www.nhlbi.nih.gov/health/health-topics/topics/thalassemia/signs. 16 September 2016.
  28. Web site: Iron Chelation. 15 July 2020.
  29. Web site: How Are Thalassemias Treated?. NHLBI. 5 September 2016. 3 July 2012. live. https://web.archive.org/web/20160916111713/http://www.nhlbi.nih.gov/health/health-topics/topics/thalassemia/treatment. 16 September 2016.