Conceição Bettencourt Explained

Conceição Bettencourt
Fields:	Neurogenetics Neuroepigenetics
Alma Mater:	University of the Azores
Work Institutions:	UCL Queen Square Institute of Neurology
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Conceição Bettencourt works in the field of neuro-epigenetics. She studies the involvement of disrupted molecular pathways and DNA methylation in neurodegenerative diseases using human post-mortem brain tissue.^{[1] [2]} She is research fellow of the Alzheimer's Research UK^[3] and co-leads the Genetics and Omics Working Group of the international Deep Dementia Phenotyping (DEMON) network.^[4]

Education and career

Bettencourt studied Biology and Human Genetics at the University of the Azores, where she conducted her PhD on "Machado-Joseph disease: from genetic variability to clinical heterogeneity".^[5] She then trained as a postdoc in Spain and the Netherlands.^[6]

Significant publications

• Murthy . Megha . Cheng . Yun Yung . Holton . Janice L. . Bettencourt . Conceição . Neurodegenerative movement disorders: An epigenetics perspective and promise for the future . Neuropathology and Applied Neurobiology . December 2021 . 47 . 7 . 897–909 . 10.1111/nan.12757. 34318515 . 9291277 .
• Bettencourt . Conceição . Foti . Sandrine C. . Miki . Yasuo . Botia . Juan . Chatterjee . Aparajita . Warner . Thomas T. . Revesz . Tamas . Lashley . Tammaryn . Balazs . Robert . Viré . Emmanuelle . Holton . Janice L. . White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy . Acta Neuropathologica . January 2020 . 139 . 1 . 135–156 . 10.1007/s00401-019-02074-0. 31535203 . 6942018 .
• Bettencourt . Conceição . Hensman-Moss . Davina . Flower . Michael . Wiethoff . Sarah . Brice . Alexis . Goizet . Cyril . Stevanin . Giovanni . Koutsis . Georgios . Karadima . Georgia . Panas . Marios . Yescas-Gómez . Petra . García-Velázquez . Lizbeth Esmeralda . Alonso-Vilatela . María Elisa . Lima . Manuela . Raposo . Mafalda . Traynor . Bryan . Sweeney . Mary . Wood . Nicholas . Giunti . Paola . Durr . Alexandra . Holmans . Peter . Houlden . Henry . Tabrizi . Sarah J. . Jones . Lesley . DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases: DNA Repair Pathways Modify polyQ Disease Onset . Annals of Neurology . June 2016 . 79 . 6 . 983–990 . 10.1002/ana.24656. 27044000 . 4914895 .
• Bettencourt . Conceição . Forabosco . Paola . Wiethoff . Sarah . Heidari . Moones . Johnstone . Daniel M. . Botía . Juan A. . Collingwood . Joanna F. . Hardy . John . Milward . Elizabeth A. . Ryten . Mina . Houlden . Henry . Gene co-expression networks shed light into diseases of brain iron accumulation . Neurobiology of Disease . March 2016 . 87 . 59–68 . 10.1016/j.nbd.2015.12.004. 26707700 . 4731015 .
• Bettencourt . Conceição . Ryten . Mina . Forabosco . Paola . Schorge . Stephanie . Hersheson . Joshua . Hardy . John . Houlden . Henry . Insights From Cerebellar Transcriptomic Analysis Into the Pathogenesis of Ataxia . JAMA Neurology . 1 July 2014 . 71 . 7 . 831–839 . 10.1001/jamaneurol.2014.756. 24862029 . 4469030 .

Notes and References

1. Web site: Dr Conceição Bettencourt . UCL News . en . 21 January 2021.
2. Web site: "Investigadora - Conceição Bettencourt" Para assinalar o Dia Nacional dos Cientistas vamos ao encontro de Conceição Bettencourt, natural da ilha Graciosa e atualmente a trabalhar no Reino... By Açores Hoje Facebook . www.facebook.com . en.
3. Web site: Early career researchers visit the Alzheimer's Research UK head office for Connect Day 2022 . Alzheimer's Research UK.
4. Web site: The Deep Dementia Phenotyping (DEMON) Network . DEMON Network.
5. Web site: Machado-Joseph disease : from genetic variability to clinical heterogeneity . 4 August 2023.
6. Web site: 2021-01-21 . Dr Conceição Bettencourt . 2023-08-04 . www.myscience.uk . en.