Conasprella otohimeae, common name Otohime's cone, is a species of sea snail, a marine gastropod mollusk in the family Conidae, the cone snails and their allies.
Like all species within the genus Conasprella, these snails are predatory and venomous. They are capable of "stinging" humans, therefore live ones should be handled carefully or not at all.
The size of the shell varies between 22 mm and 40 mm.
This marine species occurs from Southern Japan to the Philippines.