Comins' reagent explained

The Comins' reagent is a triflyl-donating reagent that is used to synthesize vinyl triflates from the corresponding ketone enolates or dienolates.[1]

It was first reported in 1992 by Daniel Comins.[2] The vinyl triflates prepared are useful as substrates in the Suzuki reaction.[3]

See also

Notes and References

  1. Book: Mundy . Bradford P. . Ellerd . Michael G. . Favaloro . Frank G. Jr. . Name Reactions and Reagents in Organic Synthesis . 978-0471228547 . 2nd . 2005.
  2. Comins . Daniel L. . Dehghani . Ali . Pyridine-Derived Triflating Reagents: An Improved Preparation of Vinyl Triflates from Metallo Enolates . Tetrahedron Letters . 1992 . 33 . 42 . 6299–6302 . 10.1016/S0040-4039(00)60957-7.
  3. Norio Miyaura. Akira Suzuki (chemist) . Miyaura . Norio . Suzuki . Akira . Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds . Chemical Reviews . 1995 . 95 . 7 . 2457–2483 . 10.1021/cr00039a007 . 10.1.1.735.7660 .

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