| Official Name: | Comayagua |
| Settlement Type: | department |
| Mapsize: | 200px |
| Pushpin Label Position: | bottom |
| Pushpin Map Caption: | Location in Honduras |
| Coordinates: | 14.45°N -125°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Honduras |
| Subdivision Type1: | Municipalities |
| Subdivision Name1: | 21 |
| Subdivision Type2: | Villages |
| Subdivision Name2: | 281 |
| Established Title: | Founded |
| Established Date: | 28 June 1825 |
| Seat: | Comayagua |
| Government Type: | Departmental |
| Leader Title: | Gobernador |
| Leader Name: | Carlos Aguiluz Madrid (2018-2022, PNH) |
| Area Total Km2: | 5120 |
| Population Footnotes: | [1] |
| Population Total: | 511943 |
| Population As Of: | 2015 |
| Population Density Km2: | auto |
| Demographics Type1: | GDP (Nominal, 2015 US dollar) |
| Demographics1 Title1: | Total |
| Demographics1 Info1: | $1.6 billion (2023)[2] |
| Demographics1 Title2: | Per capita |
| Demographics1 Info2: | $2,400 (2023) |
| Demographics2 Title2: | Total |
| Demographics2 Info2: | $3,3 billion (2023) |
| Demographics2 Title3: | Per capita |
| Demographics2 Info3: | $5,100 (2023) |
| Timezone1: | CDT |
| Utc Offset1: | -6 |
| Postal Code Type: | Postal code |
| Postal Code: | 12101 |
| Iso Code: | HN-CM |
| Blank Name Sec1: | HDI (2021) |
| Blank Info Sec1: | 0.606[3] · 6th of 18 |
| Footnotes: | Statistics derived from Consult INE online database: Population and Housing Census 2013[4] |
Comayagua (pronounced as /es/) is one of the 18 departments (departamentos) into which Honduras is divided. The departmental capital is Comayagua.
The department covers a total surface area of 5,124 km2 and, in 2015, had an estimated population of 511,943 people.
Historically, the department produced gold, copper, cinnabar, asbestos, and silver. Gems were also mined, including opal and emerald. The area was also known for "fine" cattle.[5]