| Country: | Columbus |
| Type: | Mayoral |
| Flag Image: | Flag of Columbus, Ohio (1912–1929).gif |
| Previous Election: | 1915 Columbus, Ohio mayoral election |
| Previous Year: | 1915 |
| Next Election: | 1923 Columbus, Ohio mayoral election |
| Next Year: | 1923 |
| Election Date: | November 4, 1919 |
| Image1: | James J. Thomas 002.jpg |
| Candidate1: | James J. Thomas |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 31,188 |
| Candidate2: | George J. Karb |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 26,288 |
| Mayor | |
| Before Election: | George J. Karb |
| Before Party: | Democratic Party (United States) |
| After Election: | James J. Thomas |
| After Party: | Republican Party (United States) |
The Columbus mayoral election of 1919 was the 61st mayoral election in Columbus, Ohio. It was held on Tuesday, November 4, 1919. Incumbent Democratic mayor George J. Karb was defeated by Republican party nominee James J. Thomas.