| State: | CO |
| Type: | SH |
| Route: | 101 |
| Map: | Colorado State Highway 101 Map.svg |
| Map Notes: | Map of Bent County in southeastern Colorado with SH 101 highlighted in red |
| Length Mi: | 21.413 |
| Direction A: | South |
| Terminus A: | CR K/CR 14 in Toonerville |
| Direction B: | North |
| Terminus B: | in Las Animas |
| Counties: | Bent |
| Previous Type: | SH |
| Previous Route: | 100 |
| Next Type: | SH |
| Next Route: | 103 |
State Highway 101 (SH 101) is a 21.413miles state highway in western Bent County, Colorado, United States, that connects CR K and CR 14 in Toonerville with U.S. Route 50 (US 50) in Las Animas.
SH 101 begins at a junction with CR K and CR 14 in Toonerville. From its southern terminus it heads northerly to cross the Purgatoire River and end at US 50 in Las Animas.