| State: | CO |
| Type: | CO |
| Route: | 10 |
| Map: | Colorado State Highway 10 Map.svg |
| Map Notes: | Map of south central Colorado with SH 10 highlighted in red |
| Length Mi: | 71.968 |
| Length Round: | 3 |
| Length Ref: | [1] |
| Direction A: | West |
| Terminus A: | in Walsenburg |
| Direction B: | East |
| Terminus B: | in La Junta |
| Counties: | Huerfano, Las Animas, Pueblo, Otero |
| Previous Type: | CO |
| Previous Route: | 9 |
| Next Type: | CO |
| Next Route: | 11 |
State Highway 10 (SH 10) is a 71.968adj=midNaNadj=mid state highway in the US state of Colorado. SH 10's western terminus is at Interstate 25 (I-25) and U.S. Route 160 (US 160) in Walsenburg, and the eastern terminus is at US 50 in La Junta.
SH 10 begins at an interchange with I-25 east of Walsenburg. It then heads east-northeast in a straight line, passing through Las Animas County and Pueblo County, before entering Otero County. The highway then turns due east, intersecting SH 71 in Hawley, before terminating at US 50 in La Junta.
The route was established in the 1920s, when it began at the Utah state line near Dove Creek and went east to Walsenburg on today's Interstate 25. By 1936, a section was added pushing SH 10's terminus east to La Junta. By 1938, the route was corrected in a more straight line and most of the route was paved. The entire route was paved by 1960. The entire section from the Utah border to Walsenburg, the original alignment of the route, was relinquished in 1968.[2]