| Games: | Central American and Caribbean Games |
| Year: | 2010 |
| Noc: | COL |
| Location: | Mayagüez, Puerto Rico |
| Competitors: | 259 |
| Competitors Men: | 144 |
| Competitors Women: | 115 |
| Sports: | 23 |
| Flagbearer: | Natalia Sánchez[1] |
| Gold: | 102 |
| Silver: | 86 |
| Bronze: | 77 |
| Rank: | 3 |
The XXIst Central American and Caribbean Games were held in Mayagüez, Puerto Rico from July 17, 2010 to August 1, 2010.