| College of Medicine Building | |
| Native Name: | Bangunan Maktab Perubatan 医药学院大厦 |
| Native Name Lang: | nan |
| Location: | 16 College Road, Singapore 169854 |
| Coordinates: | 1.2804°N 103.8337°W |
| Architectural Style: | Low-rise |
| Building Type: | Government offices |
| Floor Count: | 3 |
| Management: | Ministry of Health |
| Owner: | Ministry of Health |
The College of Medicine Building (Malay: Bangunan Maktab Perubatan; Chinese: 医药学院大厦) is a historic building in Singapore, located within the grounds of the Singapore General Hospital at Outram Park, within the Bukit Merah Planning Area near Singapore's central business district. Its name comes from its former function as the location for the King Edward VII College of Medicine, the first school of medicine in British Malaya (Present day: Malaysia and Singapore).