Collagen, type XXV, alpha 1 explained

Collagen alpha-1(XXV) chain is a protein that in humans is encoded by the COL25A1 gene.^{[1] [2]}

COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC, a soluble form of COL25A1 containing the extracellular collagen domains that associates with senile plaques in Alzheimer disease (AD; MIM 104300) brains (Osada et al., 2005).[supplied by OMIM]^[2]

Interactions

Collagen, type XXV, alpha 1 has been shown to interact with Amyloid precursor protein.

Further reading

• Kakuyama H, Söderberg L, Horigome K . CLAC binds to aggregated Abeta and Abeta fragments, and attenuates fibril elongation. . Biochemistry . 44 . 47 . 15602–9 . 2006 . 16300410 . 10.1021/bi051263e . etal.
• Söderberg L, Dahlqvist C, Kakuyama H . Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates. . FEBS J. . 272 . 9 . 2231–6 . 2005 . 15853808 . 10.1111/j.1742-4658.2005.04647.x . etal. 10616/39314 . 26505595 . free .
• Osada Y, Hashimoto T, Nishimura A . CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils. . J. Biol. Chem. . 280 . 9 . 8596–605 . 2005 . 15615705 . 10.1074/jbc.M413340200 . etal. free .
• Söderberg L, Kakuyama H, Möller A . Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide-binding site. . J. Biol. Chem. . 280 . 2 . 1007–15 . 2005 . 15522881 . 10.1074/jbc.M403628200 . etal. free .
• Kowa H, Sakakura T, Matsuura Y . Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits. . Am. J. Pathol. . 165 . 1 . 273–81 . 2004 . 15215182 . 10.1016/s0002-9440(10)63295-6. 1618534. etal.
• Söderberg L, Zhukareva V, Bogdanovic N . Molecular identification of AMY, an Alzheimer disease amyloid-associated protein. . J. Neuropathol. Exp. Neurol. . 62 . 11 . 1108–17 . 2004 . 14656069 . 10.1093/jnen/62.11.1108. etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .

Notes and References

1. Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T . CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV . EMBO J . 21 . 7 . 1524–34 . Apr 2002 . 11927537 . 125364 . 10.1093/emboj/21.7.1524 .
2. Web site: Entrez Gene: COL25A1 collagen, type XXV, alpha 1.