Collagen, type XVI, alpha 1 explained

Collagen alpha-1(XVI) chain is a protein that in humans is encoded by the COL16A1 gene.^{[1] [2]}

Function

This gene encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. High levels of type XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion.^[2]

Further reading

• Yamaguchi N, Kimura S, McBride OW, Hori H, Yamada Y, Kanamori T, Yamakoshi H, Nagai Y . Molecular cloning and partial characterization of a novel collagen chain, alpha 1(XVI), consisting of repetitive collagenous domains and cysteine-containing non-collagenous segments. . J. Biochem. . 112 . 6 . 856–63 . 1993 . 10.1093/oxfordjournals.jbchem.a123989 . 1284248 .
• Ratzinger S, Grässel S, Dowejko A, Reichert TE, Bauer RJ . Induction of type XVI collagen expression facilitates proliferation of oral cancer cells. . Matrix Biology . 30 . 2 . 118–25 . 2011 . 21251976 . 10.1016/j.matbio.2011.01.001 .
• Sires UI, Dublet B, Aubert-Foucher E, van der Rest M, Welgus HG . Degradation of the COL1 domain of type XIV collagen by 92-kDa gelatinase. . J. Biol. Chem. . 270 . 3 . 1062–7 . 1995 . 7836360 . 10.1074/jbc.270.3.1062 . free .
• Tillet E, Mann K, Nischt R, Pan TC, Chu ML, Timpl R . Recombinant analysis of human alpha 1 (XVI) collagen. Evidence for processing of the N-terminal globular domain. . Eur. J. Biochem. . 228 . 1 . 160–8 . 1995 . 7882999 . 10.1111/j.1432-1033.1995.tb20245.x .
• Grässel S, Timpl R, Tan EM, Chu ML . Biosynthesis and processing of type XVI collagen in human fibroblasts and smooth muscle cells. . Eur. J. Biochem. . 242 . 3 . 576–84 . 1997 . 9022684 . 10.1111/j.1432-1033.1996.0576r.x . free .
• Ratzinger S, Grässel S, Dowejko A, Reichert TE, Bauer RJ . Induction of type XVI collagen expression facilitates proliferation of oral cancer cells. . Matrix Biology . 30 . 2 . 118–25 . March 2011 . 21251976 . 10.1016/j.matbio.2011.01.001 .
• Kassner A, Hansen U, Miosge N, Reinhardt DP, Aigner T, Bruckner-Tuderman L, Bruckner P, Grässel S . Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils. . Matrix Biol. . 22 . 2 . 131–43 . 2004 . 12782140 . 10.1016/S0945-053X(03)00008-8 .
• Kassner A, Tiedemann K, Notbohm H, Ludwig T, Mörgelin M, Reinhardt DP, Chu ML, Bruckner P, Grässel S . Molecular structure and interaction of recombinant human type XVI collagen. . J. Mol. Biol. . 339 . 4 . 835–53 . 2004 . 15165854 . 10.1016/j.jmb.2004.03.042 .
• Eble JA, Kassner A, Niland S, Mörgelin M, Grifka J, Grässel S . Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains. . J. Biol. Chem. . 281 . 35 . 25745–56 . 2006 . 16754661 . 10.1074/jbc.M509942200 . free .

External links

• Web site: COL16A1 (collagen, type XVI, alpha 1) .

Notes and References

1. Pan TC, Zhang RZ, Mattei MG, Timpl R, Chu ML . Cloning and chromosomal location of human alpha 1(XVI) collagen . Proc Natl Acad Sci U S A . 89 . 14 . 6565–9 . Aug 1992 . 1631157 . 49542 . 10.1073/pnas.89.14.6565 . 1992PNAS...89.6565P . free .
2. Web site: Entrez Gene: COL16A1 collagen, type XVI, alpha 1.