Colin Nichols Explained

Colin Nichols
Birth Name:Colin G. Nichols
Birth Place:Leicester[1]
Alma Mater:University of Leeds (BSc, PhD)
Thesis Title:The effects of changes of length and load on contractility in mammalian myocardium
Thesis Url:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355606
Thesis Year:1985
Doctoral Advisor:Brian R. Jewell[2]

Colin G. Nichols FRS is the Carl Cori Endowed Professor, and Director of the Center for Investigation of Membrane Excitability Diseases at Washington University in St. Louis, Missouri.

Education

Nichols was educated at the University of Leeds where he was awarded a Bachelor of Science degree in Biochemistry and Physiology in 1982, followed by a PhD in 1985[3] for research on cardiac muscle in mammals supervised by Brian R. Jewell.[2] [4]

Career

Following his PhD, Nichols completed postdoctoral research at the University of Maryland, College Park in the laboratory of W. Jonathan Lederer.[5] He was appointed Assistant Professor at Washington University School of Medicine in 1991 and Full Professor in 2000.[2]

Research

Nichol's research investigates the biology of ion channels, particularly potassium channels, and their role in diabetes mellitus, cardiac dysrhythmias and epilepsy.[6] [7] [8] [9] [10] [11] Nichols uses models to investigate the structure, function and regulation of ion channels, which control what cells do by controlling their electrical polarity.[1]

Awards and honours

Nichols was elected a Fellow of the Royal Society (FRS) in 2014. His nomination reads:

Fun Fact

Colin G. Nichols loves ham and cheese sandwiches, especially on fresh baguette bread.

Notes and References

  1. https://news.wustl.edu/news/Pages/27025.aspx Colin Nichols elected to Royal Society
  2. http://www.nicholslab.wustl.edu/nichols.htm Colin Nichols Laboratory
  3. PhD . Colin G.. Nichols . The effects of changes of length and load on contractility in mammalian myocardium . University of Leeds . 1985 .
  4. 3214805. 1988. Nichols. C. G.. The Anrep effect: An intrinsic myocardial mechanism. Canadian Journal of Physiology and Pharmacology. 66. 7. 924–9. Hanck. D. A.. Jewell. B. R. . 10.1139/y88-150.
  5. 1750525. 1991. Nichols. C. G.. Adenosine triphosphate-sensitive potassium channels in the cardiovascular system. The American Journal of Physiology. 261. 6 Pt 2. H1675–86. Lederer. W. J.. 10.1152/ajpheart.1991.261.6.H1675. 416641.
  6. 10.1038/362031a0. Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Nature. 362. 6415. 31–8. 1993. Ho . K. . Nichols . C. G. . Colin Nichols. Lederer . W. J. . Lytton . J. . Vassilev . P. M. . Kanazirska . M. V. . Hebert . S. C. . Steven C. Hebert . 7680431. 1993Natur.362...31H. 4332298.
  7. 10.1126/science.7716547. Cloning of the beta cell high-affinity sulfonylurea receptor: A regulator of insulin secretion. Science. 268. 5209. 423–6. 1995. Aguilar-Bryan . L. . Nichols . C.. Wechsler . S.. Clement . J.. Boyd . A.. Gonzalez . G. . Herrera-Sosa . H. . Nguy . K. . Bryan . J. . Nelson . D. . 7716547. 1995Sci...268..423A.
  8. 10.1126/science.272.5269.1785. Adenosine Diphosphate as an Intracellular Regulator of Insulin Secretion. Science. 272. 5269. 1785–7. 1996. Nichols . C. G.. Shyng . S. -L. . Nestorowicz . A.. Glaser . B.. Clement . J. P.. Gonzalez . G.. Aguilar-Bryan . L.. Permutt . M. A.. Bryan . J. . 8650576. 1996Sci...272.1785N. 24351329.
  9. 10.1124/pr.57.4.11. International Union of Pharmacology. LIV. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels. Pharmacological Reviews. 57. 4. 509–26. 2005. Kubo . Y.. Adelman . J.P.. Clapham . D.E.. Jan . L.Y.. Karschin . A.. Kurachi . Y.. Lazdunski . M.. Nichols . C.G.. Colin Nichols. Seino . S.. Vandenberg . C.A. . 16382105. 11588492.
  10. 10.1016/S0092-8674(00)80701-1. 10761930. Targeted Overactivity of β Cell KATP Channels Induces Profound Neonatal Diabetes. Cell. 100. 6. 645–654. 2000. Koster . J. . Marshall . B.A.. Ensor . N.. Corbett . J.A.. Nichols . C.G.. Colin Nichols. free.
  11. 11717159. 2001. Koster. J. C.. Tolerance for ATP-insensitive K(ATP) channels in transgenic mice. Circulation Research. 89. 11. 1022–9. Knopp. A. Flagg. T. P.. Markova. K. P.. Sha. Q. Enkvetchakul. D. Betsuyaku. T. Yamada. K. A.. Nichols. C. G. . 10.1161/hh2301.100342. free.

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