| Symbol: | Cohesin |
| Cohesin | |
| Pfam: | PF00963 |
| Pfam Clan: | CL0203 |
| Interpro: | IPR002102 |
| Scop: | 1anu |
| Cdd: | cd08546 |
In molecular biology, the cohesin domain is a protein domain. It interacts with a complementary domain, termed the dockerin domain. The cohesin-dockerin interaction is the crucial interaction for complex formation in the cellulosome.[1]
The scaffolding component of the cellulolytic bacterium Clostridium thermocellum is a non-hydrolytic protein which organises the hydrolytic enzymes into a large complex, called the cellulosome. Scaffoldin comprises a series of functional domains, amongst which is a single cellulose-binding domain and nine cohesin domains which are responsible for integrating the individual enzymatic subunits into the complex.