Cofilin 1 Explained

Cofilin 1 (non-muscle; n-cofilin), also known as CFL1, is a human gene, part of the ADF/cofilin family.

Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.^[1]

One group reports that reelin signaling leads to serine3-phosphorylation of cofilin-1, and this interaction may play a role in the reelin-related regulation of neuronal migration.^{[2] [3]}

Interactions

Cofilin 1 has been shown to interact with HSPH1^[4] and LIMK1.^{[5] [6]}

Further reading

• Maciver SK, Hussey PJ . The ADF/cofilin family: actin-remodeling proteins . Genome Biol. . 3 . 5 . reviews3007 . 2002 . 12049672 . 139363 . 10.1186/gb-2002-3-5-reviews3007 . free .
• Samstag Y, Nebl G . Interaction of cofilin with the serine phosphatases PP1 and PP2A in normal and neoplastic human T lymphocytes . Adv. Enzyme Regul. . 43 . 197–211 . 2004 . 12791392 . 10.1016/S0065-2571(02)00031-6 .
• Ogawa K, Tashima M, Yumoto Y, Okuda T, Sawada H, Okuma M, Maruyama Y . Coding sequence of human placenta cofilin cDNA . Nucleic Acids Res. . 18 . 23 . 7169 . 1991 . 2263493 . 332815 . 10.1093/nar/18.23.7169 .
• van der Steege G, Draaijers TG, Grootscholten PM, Osinga J, Anzevino R, Velonà I, Den Dunnen JT, Scheffer H, Brahe C, van Ommen GJ . A provisional transcript map of the spinal muscular atrophy (SMA) critical region . Eur. J. Hum. Genet. . 3 . 2 . 87–95 . 1995 . 7552146 . 10.1159/000472281. 46083524 .
• Davidson MM, Haslam RJ . Dephosphorylation of cofilin in stimulated platelets: roles for a GTP-binding protein and Ca2+ . Biochem. J. . 301 . Pt 1 . 41–7 . 1994 . 8037689 . 1137140 . 10.1042/bj3010041.
• Ono S, Minami N, Abe H, Obinata T . Characterization of a novel cofilin isoform that is predominantly expressed in mammalian skeletal muscle . J. Biol. Chem. . 269 . 21 . 15280–6 . 1994 . 10.1016/S0021-9258(17)36603-6 . 8195165 . free .
• Abe H, Nagaoka R, Obinata T . Cytoplasmic localization and nuclear transport of cofilin in cultured myotubes . Exp. Cell Res. . 206 . 1 . 1–10 . 1993 . 8482351 . 10.1006/excr.1993.1113 .
• Gillett GT, Fox MF, Rowe PS, Casimir CM, Povey S . Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14 . Ann. Hum. Genet. . 60 . Pt 3 . 201–11 . 1996 . 8800436 . 10.1111/j.1469-1809.1996.tb00423.x . 19565638 .
• Okada K, Takano-Ohmuro H, Obinata T, Abe H . Dephosphorylation of cofilin in polymorphonuclear leukocytes derived from peripheral blood . Exp. Cell Res. . 227 . 1 . 116–22 . 1996 . 8806458 . 10.1006/excr.1996.0256 .
• Nebl G, Meuer SC, Samstag Y . Dephosphorylation of serine 3 regulates nuclear translocation of cofilin . J. Biol. Chem. . 271 . 42 . 26276–80 . 1996 . 8824278 . 10.1074/jbc.271.42.26276 . free.
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Ott DE, Coren LV, Kane BP, Busch LK, Johnson DG, Sowder RC, Chertova EN, Arthur LO, Henderson LE . Cytoskeletal proteins inside human immunodeficiency virus type 1 virions . J. Virol. . 70 . 11 . 7734–43 . 1996 . 8892894 . 190843 . 10.1128/JVI.70.11.7734-7743.1996.
• Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K . Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization . Nature . 393 . 6687 . 809–12 . 1998 . 9655398 . 10.1038/31735 . 1998Natur.393..809Y . 4326365 .
• Rodal AA, Tetreault JW, Lappalainen P, Drubin DG, Amberg DC . Aip1p Interacts with Cofilin to Disassemble Actin Filaments . J. Cell Biol. . 145 . 6 . 1251–64 . 1999 . 10366597 . 2133144 . 10.1083/jcb.145.6.1251 .
• Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S . Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase . Science . 285 . 5429 . 895–8 . 1999 . 10436159 . 10.1126/science.285.5429.895 .
• Sumi T, Matsumoto K, Takai Y, Nakamura T . Cofilin Phosphorylation and Actin Cytoskeletal Dynamics Regulated by Rho- and Cdc42-Activated Lim-Kinase 2 . J. Cell Biol. . 147 . 7 . 1519–32 . 2000 . 10613909 . 2174243 . 10.1083/jcb.147.7.1519 .
• Adachi R, Matsui S, Kinoshita M, Nagaishi K, Sasaki H, Kasahara T, Suzuki K . Nitric oxide induces chemotaxis of neutrophil-like HL-60 cells and translocation of cofilin to plasma membranes . Int. J. Immunopharmacol. . 22 . 11 . 855–64 . 2001 . 11090694 . 10.1016/S0192-0561(00)00045-X .
• Lee K, Jung J, Kim M, Guidotti G . Interaction of the alpha subunit of Na,K-ATPase with cofilin . Biochem. J. . 353 . Pt 2 . 377–85 . 2001 . 11139403 . 1221581 . 10.1042/0264-6021:3530377 .
• Toshima J, Toshima JY, Amano T, Yang N, Narumiya S, Mizuno K . Cofilin Phosphorylation by Protein Kinase Testicular Protein Kinase 1 and Its Role in Integrin-mediated Actin Reorganization and Focal Adhesion Formation . Mol. Biol. Cell . 12 . 4 . 1131–45 . 2001 . 11294912 . 32292 . 10.1091/mbc.12.4.1131 .
• Sumi T, Matsumoto K, Shibuya A, Nakamura T . Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha . J. Biol. Chem. . 276 . 25 . 23092–6 . 2001 . 11340065 . 10.1074/jbc.C100196200 . free .

Notes and References

1. Web site: Entrez Gene: CFL1 cofilin 1 (non-muscle).
2. Chai X, Förster E, Zhao S, Bock HH, Frotscher M . Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3 . . 29 . 1 . 288–99 . January 2009 . 19129405 . 6664910 . 10.1523/JNEUROSCI.2934-08.2009 .
3. Frotscher M, Chai X, Bock HH, Haas CA, Förster E, Zhao S . Role of Reelin in the development and maintenance of cortical lamination . . 116 . 11 . 1451–5 . April 2009 . 19396394 . 10.1007/s00702-009-0228-7 . 1310387 .
4. Saito Y, Doi K, Yamagishi N, Ishihara K, Hatayama T . Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems . Biochem. Biophys. Res. Commun. . 314 . 2 . 396–402 . Feb 2004 . 14733918 . 10.1016/j.bbrc.2003.12.108 .
5. Foletta VC, Lim MA, Soosairajah J, Kelly AP, Stanley EG, Shannon M, He W, Das S, Massague J, Bernard O, Soosairaiah J . Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1 . J. Cell Biol. . 162 . 6 . 1089–98 . Sep 2003 . 12963706 . 2172847 . 10.1083/jcb.200212060 .
6. Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S . Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase . . 285 . 5429 . 895–8 . Aug 1999 . 10436159 . 10.1126/science.285.5429.895 .