Codeine 3-O-demethylase explained

Codeine 3-O-demethylase
Ec Number:	1.14.11.32

Codeine 3-O-demethylase (codeine O-demethylase, CODM) is an enzyme with systematic name codeine,2-oxoglutarate:oxygen oxidoreductase (3-O-demethylating).^[1] This enzyme catalyses the following chemical reaction

codeine + 2-oxoglutarate + O₂

\rightleftharpoons morphine + formaldehyde + succinate + CO₂

Codeine 3-O-demethylase contains Fe²⁺.

Notes and References

1. Hagel JM, Facchini PJ . Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy . Nature Chemical Biology . 6 . 4 . 273–5 . April 2010 . 20228795 . 10.1038/nchembio.317 .