Cod-THC explained

Cod-THC (Codeine Δ9-tetrahydrocannabinol carbonate) is a synthetic codrug formed by linking tetrahydrocannabinol with codeine via a carbonate bridge. It is well absorbed orally and shows superior analgesic effects in animal studies compared to a simple mixture of the two drugs.[1] [2] [3]

See also

Notes and References

  1. Banerjee A, Hayward JJ, Trant JF . "Breaking bud": the effect of direct chemical modifications of phytocannabinoids on their bioavailability, physiological effects, and therapeutic potential . Organic & Biomolecular Chemistry . 21 . 18 . 3715–3732 . May 2023 . 36825573 . 10.1039/d3ob00068k . 256792029 .
  2. US . 2008/0176885 . Novel synergistic opioid-cannabinoid codrug for pain management. . Holtman JR, Crooks PA, Dhooper HK . University of Kentucky . Insys Therapeutics Inc. . 24 July 2008 .
  3. Book: Crooks PA, Dhooper HK, Chakraborty U . Improving the Use of Drug Combination through the Codrug Approach . Rautio J . Prodrugs and Targeted Delivery: Towards Better ADME Properties. . Wiley . 2011 . 978-3-527-63318-0 . 345–383 (374–376) .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Cod-THC".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.