Cob(II)yrinic acid a,c-diamide reductase explained

cob(II)yrinic acid a,c-diamide reductase
Ec Number:	1.16.8.1
Go Code:	0043784

In enzymology, a cob(II)yrinic acid a,c-diamide reductase is an enzyme that catalyzes the chemical reaction

2 cob(I)yrinic acid a,c-diamide + FMN + 3 H⁺

\rightleftharpoons 2 cob(II)yrinic acid a,c-diamide + FMNH₂

The three substrates of this enzyme are cob(I)yrinic acid a,c-diamide, flavin mononucleotide, and H⁺; its two products are cob(II)yrinic acid a,c-diamide and FMNH2.

Classification

This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with a flavin as acceptor.

Nomenclature

The systematic name of this enzyme class is cob(I)yrinic acid-a,c-diamide:FMN oxidoreductase. This enzyme is also called CobR and cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase (incorrect).

Biological role

This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B₁₂) in bacteria.

See also

• Cobalamin biosynthesis

References

• Blanche F, Maton L, Debussche L, Thibaut D . 1992 . Purification and characterization of Cob(II)yrinic acid a,c-diamide reductase from Pseudomonas denitrificans . J. Bacteriol. . 174 . 7452 - 4 . 1429467 . 22 . 207442 .
• Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC . 2002 . The biosynthesis of adenosylcobalamin (vitamin B₁₂) . Nat. Prod. Rep. . 19 . 390 - 412 . 12195810 . 10.1039/b108967f . 4 .