Cob(II)alamin reductase explained

cob(II)alamin reductase
Ec Number:	1.16.1.4
Cas Number:	37256-40-9
Go Code:	0050453

In enzymology, a cob(II)alamin reductase is an enzyme that catalyzes the chemical reaction

2 cob(I)alamin + NAD⁺

\rightleftharpoons 2 cob(II)alamin + NADH + H⁺

Thus, the two substrates of this enzyme are cob(I)alamin and NAD⁺, whereas its 3 products are cob(II)alamin, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cob(I)alamin:NAD+ oxidoreductase. Other names in common use include vitamin B12r reductase, B12r reductase, and NADH2:cob(II)alamin oxidoreductase. This enzyme participates in porphyrin and chlorophyll metabolism. It employs one cofactor, FAD.

References

• Walker GA, Murphy S, Huennekens FM . 1969 . Enzymatic conversion of vitamin B 12a to adenosyl-B 12: evidence for the existence of two separate reducing systems . Arch. Biochem. Biophys. . 134 . 95 - 102 . 4390543 . 10.1016/0003-9861(69)90255-0 . 1 .