Coagulation factor XIII B chain explained

Coagulation factor XIII B chain is a protein that in humans is encoded by the F13B gene.^{[1] [2]}

This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.^[3]

Interactions

F13B has been shown to interact with Coagulation factor XIII A chain.^{[4] [5]}

Further reading

• Muszbek L, Adány R, Mikkola H . Novel aspects of blood coagulation factor XIII. I. Structure, distribution, activation, and function. . Critical Reviews in Clinical Laboratory Sciences . 33 . 5 . 357–421 . 1997 . 8922891 . 10.3109/10408369609084691 .
• Murdock PJ, Owens DL, Chitolie A . Development and evaluation of ELISAs for factor XIIIA and XIIIB subunits in plasma. . Thromb. Res. . 67 . 1 . 73–9 . 1992 . 1359667 . 10.1016/0049-3848(92)90259-D . etal.
• Nishimura DY, Leysens NJ, Murray JC . A dinucleotide repeat for the D1S53 locus. . Nucleic Acids Res. . 20 . 5 . 1167 . 1992 . 1549502 . 10.1093/nar/20.5.1167. 312140 .
• Saito M, Asakura H, Yoshida T . A familial factor XIII subunit B deficiency. . Br. J. Haematol. . 74 . 3 . 290–4 . 1990 . 2334637 . 10.1111/j.1365-2141.1990.tb02585.x . etal.
• Greenberg CS, Dobson JV, Miraglia CC . Regulation of plasma factor XIII binding to fibrin in vitro. . Blood . 66 . 5 . 1028–34 . 1985 . 10.1182/blood.V66.5.1028.1028 . 2413926 . free .
• Carrell NA, Erickson HP, McDonagh J . Electron microscopy and hydrodynamic properties of factor XIII subunits. . J. Biol. Chem. . 264 . 1 . 551–6 . 1989 . 10.1016/S0021-9258(17)31294-2 . 2491853 . free .
• Webb GC, Coggan M, Ichinose A, Board PG . Localization of the coagulation factor XIII B subunit gene (F13B) to chromosome bands 1q31-32.1 and restriction fragment length polymorphism at the locus. . Hum. Genet. . 81 . 2 . 157–60 . 1989 . 2563250 . 10.1007/BF00293893 . 10282464 .
• Grundmann U, Amann E, Zettlmeissl G, Küpper HA . Characterization of cDNA coding for human factor XIIIa. . Proc. Natl. Acad. Sci. U.S.A. . 83 . 21 . 8024–8 . 1986 . 2877457 . 10.1073/pnas.83.21.8024 . 386859 . 1986PNAS...83.8024G . free .
• Ichinose A, McMullen BA, Fujikawa K, Davie EW . Amino acid sequence of the b subunit of human factor XIII, a protein composed of ten repetitive segments. . Biochemistry . 25 . 16 . 4633–8 . 1986 . 3021194 . 10.1021/bi00364a027 .
• Bender K, Bissbort S, Klein A . Coagulation factor XIII: genetic linkage studies with F13B. . Genet. Epidemiol. . 4 . 1 . 43–9 . 1987 . 3471677 . 10.1002/gepi.1370040106 . 46436854 . etal.
• Kaczmarek E, Liu Y, Berse B . Biosynthesis of plasma factor XIII: evidence for transcription and translation in hepatoma cells. . Biochim. Biophys. Acta . 1247 . 1 . 127–34 . 1995 . 7873582 . 10.1016/0167-4838(94)00167-f. etal.
• Hashiguchi T, Saito M, Morishita E . Two genetic defects in a patient with complete deficiency of the b-subunit for coagulation factor XIII. . Blood . 82 . 1 . 145–50 . 1993 . 10.1182/blood.V82.1.145.bloodjournal821145 . 8324218 . etal. free .
• Radek JT, Jeong JM, Wilson J, Lorand L . Association of the A subunits of recombinant placental factor XIII with the native carrier B subunits from human plasma. . Biochemistry . 32 . 14 . 3527–34 . 1993 . 8466897 . 10.1021/bi00065a002 .
• Siebenlist KR, Meh DA, Mosesson MW . Plasma factor XIII binds specifically to fibrinogen molecules containing gamma chains. . Biochemistry . 35 . 32 . 10448–53 . 1996 . 8756701 . 10.1021/bi9606206 .
• Kaetsu H, Hashiguchi T, Foster D, Ichinose A . Expression and release of the a and b subunits for human coagulation factor XIII in baby hamster kidney (BHK) cells. . J. Biochem. . 119 . 5 . 961–9 . 1997 . 8797098 . 10.1093/oxfordjournals.jbchem.a021336.
• Sugimura D, Fukue H, Arai M . [Changes of factor XIII a and b subunit in patients with disseminated intravascular coagulation syndrome] . Rinsho Byori . 44 . 4 . 355–61 . 1996 . 8847818 . etal.
• Achyuthan KE, Rowland TC, Birckbichler PJ . Hierarchies in the binding of human factor XIII, factor XIIIa, and endothelial cell transglutaminase to human plasma fibrinogen, fibrin, and fibronectin. . Mol. Cell. Biochem. . 162 . 1 . 43–9 . 1997 . 8905624 . 10.1007/bf00250994. 23583301 . etal.

Notes and References

1. Grundmann U, Nerlich C, Rein T, Zettlmeissl G . Complete cDNA sequence encoding the B subunit of human factor XIII . Nucleic Acids Res . 18 . 9 . 2817–8 . Jun 1990 . 2339067 . 330776 . 10.1093/nar/18.9.2817 .
2. Bottenus RE, Ichinose A, Davie EW . Nucleotide sequence of the gene for the b subunit of human factor XIII . Biochemistry . 29 . 51 . 11195–209 . Feb 1991 . 2271707 . 10.1021/bi00503a007 .
3. Web site: Entrez Gene: F13B coagulation factor XIII, B polypeptide.
4. Carrell . N A . Erickson H P. McDonagh J . Jan 1989 . Electron microscopy and hydrodynamic properties of factor XIII subunits . J. Biol. Chem. . 264 . 1 . 551–6 . UNITED STATES. 10.1016/S0021-9258(17)31294-2 . 0021-9258. 2491853 . free .
5. Achyuthan . K E . Rowland T C. Birckbichler P J. Lee K N. Bishop P D. Achyuthan A M . Sep 1996 . Hierarchies in the binding of human factor XIII, factor XIIIa, and endothelial cell transglutaminase to human plasma fibrinogen, fibrin, and fibronectin . Mol. Cell. Biochem. . 162 . 1 . 43–9 . NETHERLANDS. 0300-8177. 8905624 . 10.1007/bf00250994. 23583301 .