CoB—CoM heterodisulfide reductase explained
| CoB—CoM heterodisulfide reductase |
| Ec Number: | 1.8.98.1 |
| Cas Number: | 116515-35-6 |
| Go Code: | 0051912 |
In enzymology, a CoB—CoM heterodisulfide reductase is an enzyme that catalyzes the chemical reaction
coenzyme B + coenzyme M + methanophenazine
N--O
3-phospho-L-threonine + dihydromethanophenazine
The 3 substrates of this enzyme are coenzyme B, coenzyme M, and methanophenazine, whereas its two products are N--O3-phospho-L-threonine and dihydromethanophenazine.
This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with other, known, acceptors. The systematic name of this enzyme class is coenzyme B:coenzyme M:methanophenazine oxidoreductase. Other names in common use include heterodisulfide reductase, and soluble heterodisulfide reductase. This enzyme participates in folate biosynthesis.
References
- Hedderich R, Berkessel A, Thauer RK . 1990 . Purification and properties of heterodisulfide reductase from Methanobacterium thermoautotrophicum (strain Marburg) . Eur. J. Biochem. . 193 . 255 - 61 . 2121478 . 10.1111/j.1432-1033.1990.tb19331.x . 1 . free .
- Abken HJ, Tietze M, Brodersen J, Baumer S, Beifuss U, Deppenmeier U . 1998 . Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei Go1 . J. Bacteriol. . 180 . 2027 - 32 . 9555882 . 8 . 107126 .
- Simianu M, Murakami E, Brewer JM, Ragsdale SW . 1998 . Purification and properties of the heme- and iron-sulfur-containing heterodisulfide reductase from Methanosarcina thermophila . Biochemistry . 37 . 10027 - 39 . 9665708 . 10.1021/bi9726483 . 28 .
- Murakami E, Deppenmeier U, Ragsdale SW . 2001 . Characterization of the intramolecular electron transfer pathway from 2-hydroxyphenazine to the heterodisulfide reductase from Methanosarcina thermophila . J. Biol. Chem. . 276 . 2432 - 9 . 11034998 . 10.1074/jbc.M004809200 . 4 . free .
