CoA-glutathione reductase explained

CoA-glutathione reductase
Ec Number:	1.8.1.10
Cas Number:	37256-33-0
Go Code:	0050452

In enzymology, a CoA-glutathione reductase is an enzyme that catalyzes the chemical reaction

CoA + glutathione + NADP⁺

\rightleftharpoons CoA-glutathione + NADPH + H⁺

The 3 substrates of this enzyme are CoA, glutathione, and NADP⁺, whereas its 3 products are CoA-glutathione, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glutathione:NADP+ oxidoreductase (CoA-acylating). Other names in common use include coenzyme A glutathione disulfide reductase, NADPH-dependent coenzyme A-SS-glutathione reductase, coenzyme A disulfide-glutathione reductase, and NADPH:CoA-glutathione oxidoreductase. This enzyme participates in cysteine metabolism. It employs one cofactor, FAD.

References

• Ondarza RN, Abney R, Lopez-Colome AM . 1969 . Characterization of a NADPH-dependent coenzyme A-SS-glutathione reductase from yeast . Biochim. Biophys. Acta . 191 . 239 - 48 . 4390951 . 2 . 10.1016/0005-2744(69)90243-5.
• Ondarza RN, Escamilla E, Gutierrez J, De la Chica G . 1974 . CoAS-Sglutathione and GSSG reductases from rat liver. Two disulfide oxidoreductase activities in one protein entity . Biochim. Biophys. Acta . 341 . 162 - 71 . 4151341 . 1 . 10.1016/0005-2744(74)90076-x.
• Carlberg I, Mannervik B . 1977 . Purification by affinity chromatography of yeast glutathione reductase, the enzyme responsible for the NADPH-dependent reduction of the mixed disulfide of coenzyme A and glutathione . Biochim. Biophys. Acta . 484 . 268 - 74 . 334266 . 2 . 10.1016/0005-2744(77)90083-3.