CoA-disulfide reductase explained
| CoA-disulfide reductase |
| Ec Number: | 1.8.1.14 |
| Cas Number: | 206770-55-0 |
| Go Code: | 0050451 |
In enzymology, a CoA-disulfide reductase is an enzyme that catalyzes the chemical reaction
2 CoA + NAD(P)+
CoA-disulfide + NAD(P)H + H
+The 3 substrates of this enzyme are CoA, NAD+, and NADP+, whereas its 4 products are CoA-disulfide, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is CoA:NAD(P)+ oxidoreductase. Other names in common use include CoA-disulfide reductase (NADH2), NADH2:CoA-disulfide oxidoreductase, CoA:NAD+ oxidoreductase, CoADR, and coenzyme A disulfide reductase.
References
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- delCardayre SB, Stock KP, Newton GL, Fahey RC, Davies JE . 1998 . Coenzyme A disulfide reductase, the primary low molecular weight disulfide reductase from Staphylococcus aureus. Purification and characterization of the native enzyme . J. Biol. Chem. . 273 . 5744 - 51 . 9488707 . 10.1074/jbc.273.10.5744 . 10 . free .
- Luba J, Charrier V, Claiborne A . 1999 . Coenzyme A-disulfide reductase from Staphylococcus aureus: evidence for asymmetric behavior on interaction with pyridine nucleotides . Biochemistry . 38 . 2725 - 37 . 10052943 . 10.1021/bi9825899 . 9 .
- Crane EJ 3rd . 2005 . Discovery and characterization of a Coenzyme A disulfide reductase from Pyrococcus horikoshii. Implications for this disulfide metabolism of anaerobic hyperthermophiles . FEBS J. . 272 . 1189 - 200 . 15720393 . 10.1111/j.1742-4658.2005.04555.x . Ward . DE . Feasel . JM . Lancaster . KM . Murphy . RD . Mallet . TC . Crane Ej . 3rd . 5 .
