Clostridium scindens explained
Clostridium scindens is a species of bacteria in the genus Clostridium that are found in the human gut.
Like other members of the genus Clostridium, C. scindens is a Gram positive spore-forming anaerobe.[1]
Clostridium scindens is capable of converting primary bile acids to toxic secondary bile acids, as well as converting glucocorticoids to androgens by side-chain cleavage.[2]
Clostridium scindens may become established in the human colon, and its presence is associated with resistance to infection by Clostridioides difficile, due to production of secondary bile acids which inhibit the growth of C. difficile.[3] [4]
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Notes and References
- MORRIS . G. N. . WINTER . J. . CATO . E. P. . RITCHIE . A. E. . BOKKENHEUSER . V. D.YR 1985 . Clostridium scindens sp. nov., a Human Intestinal Bacterium with Desmolytic Activity on Corticoids . International Journal of Systematic and Evolutionary Microbiology . 1985 . 35 . 4 . 478–481 . 10.1099/00207713-35-4-478 . 1466-5034. free .
- Ridlon. J. M.. Ikegawa. S.. Alves. J. M. P.. Zhou. B.. Kobayashi. A.. Iida. T.. Mitamura. K.. Tanabe. G.. Serrano. M.. De Guzman. A.. Cooper. P.. Buck. G. A.. Hylemon. P. B.. Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens. The Journal of Lipid Research. 15 June 2013. 54. 9. 2437–2449. 10.1194/jlr.M038869 . free . 23772041. 3735941.
- 10.1038/nature13828. 25337874. 4354891. Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature. 517. 7533. 205–208. 2015. Buffie. Charlie G.. Bucci. Vanni. Stein. Richard R.. McKenney. Peter T.. Ling. Lilan. Gobourne. Asia. No. Daniel. Liu. Hui. Kinnebrew. Melissa. Viale. Agnes. Littmann. Eric. Van Den Brink. Marcel R. M.. Jenq. Robert R.. Taur. Ying. Sander. Chris. Cross. Justin R.. Toussaint. Nora C.. Xavier. Joao B.. Pamer. Eric G.. 2015Natur.517..205B.
- Studer . Nicolas . Desharnais . Lyne . Beutler . Markus . Brugiroux . Sandrine . Terrazos . Miguel A. . Menin . Laure . Schürch . Christian M. . McCoy . Kathy D. . Kuehne . Sarah A. . Minton . Nigel P. . Stecher . Bärbel . Bernier-Latmani . Rizlan . Hapfelmeier . Siegfried . 2016 . Functional Intestinal Bile Acid 7α-Dehydroxylation by Clostridium scindens Associated with Protection from Clostridium difficile Infection in a Gnotobiotic Mouse Model . Frontiers in Cellular and Infection Microbiology . 6 . 191 . 10.3389/fcimb.2016.00191 . 28066726 . 5168579 . 2235-2988. free .
